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- NCIT_C179171 IAO_0000115 "A bi-steric inhibitor of the raptor-mammalian target of rapamycin (mTOR) complex 1 (mTOR complex 1; mTORC1), with potential antineoplastic activity. Upon administration, mTORC1 kinase inhibitor RMC-5552 selectively targets, binds to and inhibits the serine/threonine kinase activity of mTORC1, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTORC1 phosphorylates transcription factors, such as ribosomal protein S6 kinase beta-1 (S6K1) and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival. RMC-5552 is able to suppress the phosphorylation of the tumor suppressor activity of 4EBP1, induces apoptosis and decreases proliferation of mTORC1-expressing tumor cells. mTORC1 is a serine/threonine kinase that is upregulated in certain tumor cell types. It plays an important role in the PI3K/Akt/mTOR signaling pathway, which is often deregulated in cancer cells and promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. Selective mTORC1 inhibition improves the poor clinical tolerability as compared to agents that also cause inhibition of the mTORC2 complex." @default.
- NCIT_C179171 NCIT_A7 NCIT_C96314 @default.
- NCIT_C179171 NCIT_NHC0 "C179171" @default.
- NCIT_C179171 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179171 NCIT_P107 "mTORC1 Kinase Inhibitor RMC-5552" @default.
- NCIT_C179171 NCIT_P108 "mTORC1 Kinase Inhibitor RMC-5552" @default.
- NCIT_C179171 NCIT_P208 "CL1648463" @default.
- NCIT_C179171 NCIT_P322 "CTRP" @default.
- NCIT_C179171 NCIT_P322 "GDC" @default.
- NCIT_C179171 NCIT_P399 "804998" @default.
- NCIT_C179171 normalizedInformationContent "100" @default.
- NCIT_C179171 referenceCount "1" @default.
- NCIT_C179171 hasExactSynonym "RMC 5552" @default.
- NCIT_C179171 hasExactSynonym "RMC-5552" @default.
- NCIT_C179171 hasExactSynonym "RMC5552" @default.
- NCIT_C179171 hasExactSynonym "mTORC1 Kinase Inhibitor RMC-5552" @default.
- NCIT_C179171 inSubset NCIT_C116977 @default.
- NCIT_C179171 inSubset NCIT_C116978 @default.
- NCIT_C179171 inSubset NCIT_C128784 @default.
- NCIT_C179171 inSubset NCIT_C157711 @default.
- NCIT_C179171 inSubset NCIT_C157712 @default.
- NCIT_C179171 inSubset NCIT_C176424 @default.
- NCIT_C179171 type Class @default.
- NCIT_C179171 isDefinedBy ncit.owl @default.
- NCIT_C179171 label "mTORC1 Kinase Inhibitor RMC-5552" @default.
- NCIT_C179171 subClassOf NCIT_C129824 @default.
- NCIT_C179171 subClassOf NCIT_C129825 @default.
- NCIT_C179171 subClassOf NCIT_C1404 @default.
- NCIT_C179171 subClassOf NCIT_C163758 @default.
- NCIT_C179171 subClassOf NCIT_C179171 @default.
- NCIT_C179171 subClassOf NCIT_C1908 @default.
- NCIT_C179171 subClassOf NCIT_C1909 @default.
- NCIT_C179171 subClassOf NCIT_C2189 @default.
- NCIT_C179171 subClassOf NCIT_C2201 @default.
- NCIT_C179171 subClassOf NCIT_C274 @default.
- NCIT_C179171 subClassOf NCIT_C471 @default.
- NCIT_C179171 subClassOf NCIT_C61074 @default.