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- NCIT_C179196 IAO_0000115 "An immunoglobulin G1 (IgG1) bispecific antibody targeting both epidermal growth factor receptor (EGFR; HER1; ErbB1) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, anti-EGFR/LGR5 bispecific antibody MCLA-158 simultaneously targets and binds to both EGFR and LGR5, thereby inhibiting the activation of both EGFR- and LGR5-mediated signaling pathways. This results in the inhibition of tumor cell proliferation. EGFR, a receptor tyrosine kinase (RTK) upregulated and/or mutated in a variety of tumor cell types, plays an important role in tumor cell proliferation. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival." @default.
- NCIT_C179196 NCIT_A7 NCIT_C17068 @default.
- NCIT_C179196 NCIT_NHC0 "C179196" @default.
- NCIT_C179196 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179196 NCIT_P107 "Anti-EGFR/LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 NCIT_P108 "Anti-EGFR/LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 NCIT_P208 "CL1648437" @default.
- NCIT_C179196 NCIT_P322 "CTRP" @default.
- NCIT_C179196 NCIT_P322 "GDC" @default.
- NCIT_C179196 NCIT_P399 "805707" @default.
- NCIT_C179196 normalizedInformationContent "100" @default.
- NCIT_C179196 referenceCount "1" @default.
- NCIT_C179196 hasExactSynonym "Anti-EGFR/Anti-LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 hasExactSynonym "Anti-EGFR/LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 hasExactSynonym "EGFR x LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 hasExactSynonym "MCLA 158" @default.
- NCIT_C179196 hasExactSynonym "MCLA-158" @default.
- NCIT_C179196 hasExactSynonym "MCLA158" @default.
- NCIT_C179196 inSubset NCIT_C116977 @default.
- NCIT_C179196 inSubset NCIT_C116978 @default.
- NCIT_C179196 inSubset NCIT_C128784 @default.
- NCIT_C179196 inSubset NCIT_C157711 @default.
- NCIT_C179196 inSubset NCIT_C157712 @default.
- NCIT_C179196 inSubset NCIT_C176424 @default.
- NCIT_C179196 type Class @default.
- NCIT_C179196 isDefinedBy ncit.owl @default.
- NCIT_C179196 label "Anti-EGFR/LGR5 Bispecific Antibody MCLA-158" @default.
- NCIT_C179196 subClassOf NCIT_C129821 @default.
- NCIT_C179196 subClassOf NCIT_C129822 @default.
- NCIT_C179196 subClassOf NCIT_C1454 @default.
- NCIT_C179196 subClassOf NCIT_C179196 @default.
- NCIT_C179196 subClassOf NCIT_C1908 @default.
- NCIT_C179196 subClassOf NCIT_C1909 @default.
- NCIT_C179196 subClassOf NCIT_C274 @default.
- NCIT_C179196 subClassOf NCIT_C307 @default.
- NCIT_C179196 subClassOf NCIT_C308 @default.