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- NCIT_C179214 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6) conjugated to deruxtecan, which is comprised of an enzymatically cleavable tetrapeptide-based linker and MAAA-1181a (DXd), the cytotoxic DNA topoisomerase I inhibitor derivative of exatecan, with potential antineoplastic activity. Upon administration of raludotatug deruxtecan, raludotatug targets and binds to CDH6-expressing tumor cells. Upon cellular uptake and lysosomal degradation of the linker, DXd targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits the proliferation of CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed by a variety of cancers, plays a key role in tumor cell proliferation." @default.
- NCIT_C179214 NCIT_A7 NCIT_C177731 @default.
- NCIT_C179214 NCIT_NHC0 "C179214" @default.
- NCIT_C179214 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179214 NCIT_P107 "Raludotatug Deruxtecan" @default.
- NCIT_C179214 NCIT_P108 "Raludotatug Deruxtecan" @default.
- NCIT_C179214 NCIT_P208 "CL1662077" @default.
- NCIT_C179214 NCIT_P210 "2610074-57-0" @default.
- NCIT_C179214 NCIT_P319 "BPQ010OFD7" @default.
- NCIT_C179214 NCIT_P322 "CTRP" @default.
- NCIT_C179214 NCIT_P322 "FDA" @default.
- NCIT_C179214 NCIT_P322 "GDC" @default.
- NCIT_C179214 NCIT_P399 "804812" @default.
- NCIT_C179214 normalizedInformationContent "100" @default.
- NCIT_C179214 referenceCount "1" @default.
- NCIT_C179214 hasExactSynonym "Anti-CDH-6 ADC DS-6000a" @default.
- NCIT_C179214 hasExactSynonym "Anti-CDH6 ADC DS-6000a" @default.
- NCIT_C179214 hasExactSynonym "Anti-CDH6 Antibody-drug Conjugate DS-6000a" @default.
- NCIT_C179214 hasExactSynonym "Anti-CDH6/DXd ADC DS-6000a" @default.
- NCIT_C179214 hasExactSynonym "DS 6000a" @default.
- NCIT_C179214 hasExactSynonym "DS-6000" @default.
- NCIT_C179214 hasExactSynonym "DS-6000a" @default.
- NCIT_C179214 hasExactSynonym "DS6000a" @default.
- NCIT_C179214 hasExactSynonym "RALUDOTATUG DERUXTECAN" @default.
- NCIT_C179214 hasExactSynonym "Raludotatug Deruxtecan" @default.
- NCIT_C179214 inSubset NCIT_C116977 @default.
- NCIT_C179214 inSubset NCIT_C116978 @default.
- NCIT_C179214 inSubset NCIT_C128784 @default.
- NCIT_C179214 inSubset NCIT_C157711 @default.
- NCIT_C179214 inSubset NCIT_C157712 @default.
- NCIT_C179214 inSubset NCIT_C176424 @default.
- NCIT_C179214 inSubset NCIT_C63923 @default.
- NCIT_C179214 type Class @default.
- NCIT_C179214 isDefinedBy ncit.owl @default.
- NCIT_C179214 label "Raludotatug Deruxtecan" @default.
- NCIT_C179214 subClassOf NCIT_C129821 @default.
- NCIT_C179214 subClassOf NCIT_C129823 @default.
- NCIT_C179214 subClassOf NCIT_C1512 @default.
- NCIT_C179214 subClassOf NCIT_C179214 @default.
- NCIT_C179214 subClassOf NCIT_C1908 @default.
- NCIT_C179214 subClassOf NCIT_C1909 @default.
- NCIT_C179214 subClassOf NCIT_C274 @default.
- NCIT_C179214 subClassOf NCIT_C307 @default.
- NCIT_C179214 subClassOf NCIT_C308 @default.