Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C179231> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- NCIT_C179231 IAO_0000115 "A peptide-based cancer vaccine composed of the adjuvant Amphiphile (Amph; AMP)-CpG-7909, which is a lipid-conjugated immune-stimulatory oligonucleotide, admixed with Amph modified Kirsten Rat Sarcoma (KRAS) mutated peptides, which contain a mixture of lipid-conjugated peptide-based antigens, with potential immunostimulatory and antitumor activities. Upon subcutaneous administration of the AMP KRAS vaccine ELI-002, the lipid moieties bind to tissue albumin and the complex is delivered to and accumulates in the lymph nodes where it is taken up by antigen presenting cells (APCs), primarily dendritic cells (DCs). This may stimulate the host immune system to mount a cytotoxic T-cell lymphocyte (CTL)-mediated immune response against KRAS/neuroblastoma ras viral oncogene homolog (NRAS)-expressing tumor cells. KRAS and NRAS, tumor-associated antigens (TAAs) that are involved in the RAS/mitogen-activated protein kinase (MAPK) signaling pathway, are overexpressed on a variety of tumor cell types and play key role in tumor cell proliferation. The CpG-based adjuvant may enhance the mutated KRAS T cell-specific immune response. ELI-002 2P contains two KRAS mutated Amph-peptides, including Amph-G12D and Amph-G12R. ELI-002 (ELI-002 7P) contains seven KRAS mutated Amph-peptides (Amph-Peptide 7), including G12D, G12R, G12V, G12A, G12C, G12S and G13D." @default.
- NCIT_C179231 NCIT_A7 NCIT_C98369 @default.
- NCIT_C179231 NCIT_NHC0 "C179231" @default.
- NCIT_C179231 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C179231 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179231 NCIT_P107 "AMP KRAS Vaccine ELI-002" @default.
- NCIT_C179231 NCIT_P108 "AMP KRAS Vaccine ELI-002" @default.
- NCIT_C179231 NCIT_P208 "CL1662063" @default.
- NCIT_C179231 NCIT_P322 "CTRP" @default.
- NCIT_C179231 NCIT_P322 "GDC" @default.
- NCIT_C179231 NCIT_P399 "805539" @default.
- NCIT_C179231 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179231 NCIT_R124 NCIT_C17930 @default.
- NCIT_C179231 NCIT_R124 NCIT_C17937 @default.
- NCIT_C179231 NCIT_R124 NCIT_C18839 @default.
- NCIT_C179231 NCIT_R124 NCIT_C21124 @default.
- NCIT_C179231 NCIT_R124 NCIT_C45548 @default.
- NCIT_C179231 normalizedInformationContent "100" @default.
- NCIT_C179231 referenceCount "1" @default.
- NCIT_C179231 hasExactSynonym "AMP KRAS Vaccine ELI-002" @default.
- NCIT_C179231 hasExactSynonym "Amphiphile mKRAS Peptides/Amp CpG-7909 ELI-002" @default.
- NCIT_C179231 hasExactSynonym "ELI 002" @default.
- NCIT_C179231 hasExactSynonym "ELI-002" @default.
- NCIT_C179231 hasExactSynonym "ELI002" @default.
- NCIT_C179231 hasExactSynonym "Vaccine ELI-002" @default.
- NCIT_C179231 hasExactSynonym "mKRAS Vaccine ELI-002" @default.
- NCIT_C179231 inSubset NCIT_C116977 @default.
- NCIT_C179231 inSubset NCIT_C116978 @default.
- NCIT_C179231 inSubset NCIT_C128784 @default.
- NCIT_C179231 inSubset NCIT_C157711 @default.
- NCIT_C179231 inSubset NCIT_C157712 @default.
- NCIT_C179231 inSubset NCIT_C176424 @default.
- NCIT_C179231 type Class @default.
- NCIT_C179231 isDefinedBy ncit.owl @default.
- NCIT_C179231 label "AMP KRAS Vaccine ELI-002" @default.
- NCIT_C179231 subClassOf NCIT_C129820 @default.
- NCIT_C179231 subClassOf NCIT_C1663 @default.
- NCIT_C179231 subClassOf NCIT_C1752 @default.
- NCIT_C179231 subClassOf NCIT_C179231 @default.
- NCIT_C179231 subClassOf NCIT_C1908 @default.
- NCIT_C179231 subClassOf NCIT_C1909 @default.
- NCIT_C179231 subClassOf NCIT_C274 @default.
- NCIT_C179231 subClassOf NCIT_C307 @default.
- NCIT_C179231 subClassOf NCIT_C308 @default.
- NCIT_C179231 subClassOf NCIT_C923 @default.