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- NCIT_C179265 IAO_0000115 "An orally bioavailable selective estrogen receptor degrader/downregulator (SERD) and a structural analog of fulvestrant, with potential antineoplastic activity. Upon oral administration, SERD ZB-716 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells." @default.
- NCIT_C179265 NCIT_A7 NCIT_C38361 @default.
- NCIT_C179265 NCIT_NHC0 "C179265" @default.
- NCIT_C179265 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179265 NCIT_P108 "SERD ZB-716" @default.
- NCIT_C179265 NCIT_P208 "CL1661906" @default.
- NCIT_C179265 NCIT_P210 "1853279-29-4" @default.
- NCIT_C179265 NCIT_P319 "E35ZN95LMT" @default.
- NCIT_C179265 NCIT_P322 "FDA" @default.
- NCIT_C179265 NCIT_P322 "GDC" @default.
- NCIT_C179265 NCIT_P399 "804729" @default.
- NCIT_C179265 normalizedInformationContent "100" @default.
- NCIT_C179265 referenceCount "1" @default.
- NCIT_C179265 hasExactSynonym "Borestrant" @default.
- NCIT_C179265 hasExactSynonym "SERD ZB-716" @default.
- NCIT_C179265 hasExactSynonym "Selective Estrogen Receptor Alpha Degrader ZB716" @default.
- NCIT_C179265 hasExactSynonym "Selective Estrogen Receptor Degrader ZB716" @default.
- NCIT_C179265 hasExactSynonym "ZB 716" @default.
- NCIT_C179265 hasExactSynonym "ZB-716" @default.
- NCIT_C179265 hasExactSynonym "ZB716" @default.
- NCIT_C179265 inSubset NCIT_C128784 @default.
- NCIT_C179265 inSubset NCIT_C157711 @default.
- NCIT_C179265 inSubset NCIT_C157712 @default.
- NCIT_C179265 inSubset NCIT_C176424 @default.
- NCIT_C179265 inSubset NCIT_C63923 @default.
- NCIT_C179265 type Class @default.
- NCIT_C179265 isDefinedBy ncit.owl @default.
- NCIT_C179265 label "SERD ZB-716" @default.
- NCIT_C179265 subClassOf NCIT_C129818 @default.
- NCIT_C179265 subClassOf NCIT_C147908 @default.
- NCIT_C179265 subClassOf NCIT_C163758 @default.
- NCIT_C179265 subClassOf NCIT_C179265 @default.
- NCIT_C179265 subClassOf NCIT_C1908 @default.
- NCIT_C179265 subClassOf NCIT_C1909 @default.
- NCIT_C179265 subClassOf NCIT_C2116 @default.
- NCIT_C179265 subClassOf NCIT_C274 @default.
- NCIT_C179265 subClassOf NCIT_C481 @default.
- NCIT_C179265 subClassOf NCIT_C547 @default.