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- NCIT_C179266 IAO_0000115 "A humanized monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-L1 monoclonal antibody LP002 specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. In addition, by binding to PD-L1, LP002 also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells." @default.
- NCIT_C179266 NCIT_A7 NCIT_C96024 @default.
- NCIT_C179266 NCIT_NHC0 "C179266" @default.
- NCIT_C179266 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179266 NCIT_P108 "Anti-PD-L1 Monoclonal Antibody LP002" @default.
- NCIT_C179266 NCIT_P208 "CL1661909" @default.
- NCIT_C179266 NCIT_P322 "GDC" @default.
- NCIT_C179266 NCIT_P399 "804663" @default.
- NCIT_C179266 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179266 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179266 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179266 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179266 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179266 normalizedInformationContent "100" @default.
- NCIT_C179266 referenceCount "1" @default.
- NCIT_C179266 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody LP002" @default.
- NCIT_C179266 hasExactSynonym "LP 002" @default.
- NCIT_C179266 hasExactSynonym "LP-002" @default.
- NCIT_C179266 hasExactSynonym "LP002" @default.
- NCIT_C179266 inSubset NCIT_C128784 @default.
- NCIT_C179266 inSubset NCIT_C157711 @default.
- NCIT_C179266 inSubset NCIT_C157712 @default.
- NCIT_C179266 inSubset NCIT_C176424 @default.
- NCIT_C179266 type Class @default.
- NCIT_C179266 isDefinedBy ncit.owl @default.
- NCIT_C179266 label "Anti-PD-L1 Monoclonal Antibody LP002" @default.
- NCIT_C179266 subClassOf NCIT_C128057 @default.
- NCIT_C179266 subClassOf NCIT_C129821 @default.
- NCIT_C179266 subClassOf NCIT_C129822 @default.
- NCIT_C179266 subClassOf NCIT_C141144 @default.
- NCIT_C179266 subClassOf NCIT_C143250 @default.
- NCIT_C179266 subClassOf NCIT_C156893 @default.
- NCIT_C179266 subClassOf NCIT_C163758 @default.
- NCIT_C179266 subClassOf NCIT_C179266 @default.
- NCIT_C179266 subClassOf NCIT_C1908 @default.
- NCIT_C179266 subClassOf NCIT_C1909 @default.
- NCIT_C179266 subClassOf NCIT_C191689 @default.
- NCIT_C179266 subClassOf NCIT_C20401 @default.
- NCIT_C179266 subClassOf NCIT_C274 @default.
- NCIT_C179266 subClassOf NCIT_C307 @default.
- NCIT_C179266 subClassOf NCIT_C308 @default.