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- NCIT_C179267 IAO_0000115 "An extended-release (ER) formulation of APL-1501, an orally available inhibitor of methionine aminopeptidase II type (MetAP2), with potential antiangiogenic and antineoplastic activities. Upon administration, ER MetAP2 inhibitor APL-1501 is released from the formulation over an extended period of time and targets, binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival. Compared to APL-1202, APL-1501 has improved pharmacokinetic (PK) characteristics. The ER formulation allows for controlled drug release, enhanced drug plasma exposure time and reduced medication intake frequency." @default.
- NCIT_C179267 NCIT_A7 NCIT_C143021 @default.
- NCIT_C179267 NCIT_NHC0 "C179267" @default.
- NCIT_C179267 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179267 NCIT_P108 "Extended-Release MetAP2 Inhibitor APL-1501" @default.
- NCIT_C179267 NCIT_P208 "CL1661908" @default.
- NCIT_C179267 NCIT_P322 "GDC" @default.
- NCIT_C179267 NCIT_P399 "804664" @default.
- NCIT_C179267 normalizedInformationContent "100" @default.
- NCIT_C179267 referenceCount "1" @default.
- NCIT_C179267 hasExactSynonym "APL-1301" @default.
- NCIT_C179267 hasExactSynonym "ER APL 1501" @default.
- NCIT_C179267 hasExactSynonym "ER APL-1501" @default.
- NCIT_C179267 hasExactSynonym "ER APL1501" @default.
- NCIT_C179267 hasExactSynonym "Ethionine Aminopeptidase Type II Inhibitor APL-1501" @default.
- NCIT_C179267 hasExactSynonym "Extended-Release MetAP2 Inhibitor APL-1501" @default.
- NCIT_C179267 inSubset NCIT_C128784 @default.
- NCIT_C179267 inSubset NCIT_C157711 @default.
- NCIT_C179267 inSubset NCIT_C157712 @default.
- NCIT_C179267 inSubset NCIT_C176424 @default.
- NCIT_C179267 type Class @default.
- NCIT_C179267 isDefinedBy ncit.owl @default.
- NCIT_C179267 label "Extended-Release MetAP2 Inhibitor APL-1501" @default.
- NCIT_C179267 subClassOf NCIT_C179267 @default.
- NCIT_C179267 subClassOf NCIT_C1908 @default.
- NCIT_C179267 subClassOf NCIT_C1909 @default.
- NCIT_C179267 subClassOf NCIT_C471 @default.
- NCIT_C179267 subClassOf NCIT_C783 @default.