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- NCIT_C179271 IAO_0000115 "An agonist of the intracellular innate immune adaptor stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon intravenous administration, STING agonist SNX281 targets and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by antigen-presenting cells (ADCs), including dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system." @default.
- NCIT_C179271 NCIT_A7 NCIT_C101588 @default.
- NCIT_C179271 NCIT_NHC0 "C179271" @default.
- NCIT_C179271 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179271 NCIT_P107 "STING Agonist SNX281" @default.
- NCIT_C179271 NCIT_P108 "STING Agonist SNX281" @default.
- NCIT_C179271 NCIT_P208 "CL1661904" @default.
- NCIT_C179271 NCIT_P322 "CTRP" @default.
- NCIT_C179271 NCIT_P322 "GDC" @default.
- NCIT_C179271 NCIT_P399 "804675" @default.
- NCIT_C179271 normalizedInformationContent "100" @default.
- NCIT_C179271 referenceCount "1" @default.
- NCIT_C179271 hasExactSynonym "SNX 281" @default.
- NCIT_C179271 hasExactSynonym "SNX-281" @default.
- NCIT_C179271 hasExactSynonym "SNX281" @default.
- NCIT_C179271 hasExactSynonym "STING Agonist SNX281" @default.
- NCIT_C179271 inSubset NCIT_C116977 @default.
- NCIT_C179271 inSubset NCIT_C116978 @default.
- NCIT_C179271 inSubset NCIT_C128784 @default.
- NCIT_C179271 inSubset NCIT_C157711 @default.
- NCIT_C179271 inSubset NCIT_C157712 @default.
- NCIT_C179271 inSubset NCIT_C176424 @default.
- NCIT_C179271 type Class @default.
- NCIT_C179271 isDefinedBy ncit.owl @default.
- NCIT_C179271 label "STING Agonist SNX281" @default.
- NCIT_C179271 subClassOf NCIT_C129820 @default.
- NCIT_C179271 subClassOf NCIT_C176586 @default.
- NCIT_C179271 subClassOf NCIT_C179271 @default.
- NCIT_C179271 subClassOf NCIT_C1908 @default.
- NCIT_C179271 subClassOf NCIT_C1909 @default.
- NCIT_C179271 subClassOf NCIT_C274 @default.
- NCIT_C179271 subClassOf NCIT_C308 @default.