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- NCIT_C179275 IAO_0000115 "A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, melanoma-associated antigen C2 (MAGE-C2; MC2), ALK epitope, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-C2-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes bind to tumor cells expressing the MAGE-C2 antigen, which may induce cell death in and halt the growth of MAGE-C2-expressing cancer cells. MAGE-C2, a cancer/testis tumor-associated antigen (CT-TAA), is overexpressed by a variety of cancer cell types." @default.
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- NCIT_C179275 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179275 NCIT_P108 "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes" @default.
- NCIT_C179275 NCIT_P208 "CL1661916" @default.
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- NCIT_C179275 hasExactSynonym "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes" @default.
- NCIT_C179275 hasExactSynonym "Autologous MAGE-C2/HLA-A2 TCR T-cells" @default.
- NCIT_C179275 hasExactSynonym "Autologous MC2 TCR T Cells" @default.
- NCIT_C179275 inSubset NCIT_C128784 @default.
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- NCIT_C179275 type Class @default.
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- NCIT_C179275 label "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes" @default.
- NCIT_C179275 subClassOf NCIT_C129820 @default.
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