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- NCIT_C179286 IAO_0000115 "An immunoconjugate consisting of a humanized monoclonal antibody directed against the tumor-associated antigen (TAA) disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) that is site-specifically conjugated, via a stable tri-peptide cleavable linker, to DM21, a cytotoxic maytansinoid microtubule-disrupting payload, with potential antineoplastic activity. Upon administration of izeltabart tapatansine, the anti-ADAM9 monoclonal antibody moiety targets and binds to ADAM9 on tumor cells. Upon internalization, the maytansinoid moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of tumor cells. ADAM9, belonging to the a disintegrin and metalloproteinase (ADAM) family of proteases, plays a key role in cytokine and growth factor shedding and cell migration. It is overexpressed on multiple solid tumors while minimally expressed on normal tissue. Dysregulation of ADAM9 has been implicated in tumor progression, migration and metastasis. Its expression is correlated with poor prognosis. The antibody is engineered to include a YTE mutation to improve pharmacokinetics." @default.
- NCIT_C179286 NCIT_A7 NCIT_C179212 @default.
- NCIT_C179286 NCIT_NHC0 "C179286" @default.
- NCIT_C179286 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179286 NCIT_P108 "Izeltabart Tapatansine" @default.
- NCIT_C179286 NCIT_P208 "CL1661889" @default.
- NCIT_C179286 NCIT_P210 "2642078-62-2" @default.
- NCIT_C179286 NCIT_P319 "LL3U59WXR1" @default.
- NCIT_C179286 NCIT_P322 "FDA" @default.
- NCIT_C179286 NCIT_P322 "GDC" @default.
- NCIT_C179286 NCIT_P399 "804696" @default.
- NCIT_C179286 normalizedInformationContent "100" @default.
- NCIT_C179286 referenceCount "1" @default.
- NCIT_C179286 hasExactSynonym "ADAM9-targeting Antibody-drug Conjugate IMGC936" @default.
- NCIT_C179286 hasExactSynonym "Anti-ADAM9 ADC IMGC936" @default.
- NCIT_C179286 hasExactSynonym "Anti-ADAM9 Antibody Drug Conjugate IMGC936" @default.
- NCIT_C179286 hasExactSynonym "Anti-ADAM9/DM21 ADC IMGC936" @default.
- NCIT_C179286 hasExactSynonym "IMGC 936" @default.
- NCIT_C179286 hasExactSynonym "IMGC-936" @default.
- NCIT_C179286 hasExactSynonym "IMGC936" @default.
- NCIT_C179286 hasExactSynonym "IZELTABART TAPATANSINE" @default.
- NCIT_C179286 hasExactSynonym "Izeltabart Tapatansine" @default.
- NCIT_C179286 inSubset NCIT_C128784 @default.
- NCIT_C179286 inSubset NCIT_C157711 @default.
- NCIT_C179286 inSubset NCIT_C157712 @default.
- NCIT_C179286 inSubset NCIT_C176424 @default.
- NCIT_C179286 inSubset NCIT_C63923 @default.
- NCIT_C179286 type Class @default.
- NCIT_C179286 isDefinedBy ncit.owl @default.
- NCIT_C179286 label "Izeltabart Tapatansine" @default.
- NCIT_C179286 subClassOf NCIT_C129821 @default.
- NCIT_C179286 subClassOf NCIT_C129823 @default.
- NCIT_C179286 subClassOf NCIT_C1512 @default.
- NCIT_C179286 subClassOf NCIT_C179286 @default.
- NCIT_C179286 subClassOf NCIT_C1908 @default.
- NCIT_C179286 subClassOf NCIT_C1909 @default.
- NCIT_C179286 subClassOf NCIT_C274 @default.
- NCIT_C179286 subClassOf NCIT_C307 @default.
- NCIT_C179286 subClassOf NCIT_C308 @default.