Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C179301> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- NCIT_C179301 IAO_0000115 "A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19), a single short hairpin RNA (shRNA) that disrupts the expression of beta-2 microglobulin (B2M) component of the class 1 major histocompatibility complex (MHC) molecules, and a HLA-E gene, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR T-cells PBCAR19B specifically recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The downregulation of the expression of the class 1 MHC molecule component B2M by shRNA and the HLA-E gene decrease the number of CAR T-cells that are rejected and killed by natural killer (NK) and cytotoxic T-cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.
- NCIT_C179301 NCIT_A7 NCIT_C38894 @default.
- NCIT_C179301 NCIT_NHC0 "C179301" @default.
- NCIT_C179301 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179301 NCIT_P107 "Allogeneic Anti-CD19 CAR T-cells PBCAR19B" @default.
- NCIT_C179301 NCIT_P108 "Allogeneic Anti-CD19 CAR T-cells PBCAR19B" @default.
- NCIT_C179301 NCIT_P208 "CL1661874" @default.
- NCIT_C179301 NCIT_P322 "CTRP" @default.
- NCIT_C179301 NCIT_P322 "GDC" @default.
- NCIT_C179301 NCIT_P399 "804742" @default.
- NCIT_C179301 normalizedInformationContent "100" @default.
- NCIT_C179301 referenceCount "1" @default.
- NCIT_C179301 hasExactSynonym "Allogeneic Anti-CD19 CAR T Cells PBCAR19B" @default.
- NCIT_C179301 hasExactSynonym "Allogeneic Anti-CD19 CAR T-cells PBCAR19B" @default.
- NCIT_C179301 hasExactSynonym "Allogeneic CD19 CAR T-cells PBCAR19B" @default.
- NCIT_C179301 hasExactSynonym "Allogeneic CD19-targeting CAR-T Cells PBCAR19B" @default.
- NCIT_C179301 hasExactSynonym "PBCAR19B" @default.
- NCIT_C179301 inSubset NCIT_C116977 @default.
- NCIT_C179301 inSubset NCIT_C116978 @default.
- NCIT_C179301 inSubset NCIT_C128784 @default.
- NCIT_C179301 inSubset NCIT_C157711 @default.
- NCIT_C179301 inSubset NCIT_C157712 @default.
- NCIT_C179301 inSubset NCIT_C176424 @default.
- NCIT_C179301 type Class @default.
- NCIT_C179301 isDefinedBy ncit.owl @default.
- NCIT_C179301 label "Allogeneic Anti-CD19 CAR T-cells PBCAR19B" @default.
- NCIT_C179301 subClassOf NCIT_C129820 @default.
- NCIT_C179301 subClassOf NCIT_C129821 @default.
- NCIT_C179301 subClassOf NCIT_C129826 @default.
- NCIT_C179301 subClassOf NCIT_C137999 @default.
- NCIT_C179301 subClassOf NCIT_C142078 @default.
- NCIT_C179301 subClassOf NCIT_C154231 @default.
- NCIT_C179301 subClassOf NCIT_C176018 @default.
- NCIT_C179301 subClassOf NCIT_C179301 @default.
- NCIT_C179301 subClassOf NCIT_C1908 @default.
- NCIT_C179301 subClassOf NCIT_C1909 @default.
- NCIT_C179301 subClassOf NCIT_C1962 @default.
- NCIT_C179301 subClassOf NCIT_C200765 @default.
- NCIT_C179301 subClassOf NCIT_C274 @default.
- NCIT_C179301 subClassOf NCIT_C28676 @default.
- NCIT_C179301 subClassOf NCIT_C307 @default.
- NCIT_C179301 subClassOf NCIT_C308 @default.