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- NCIT_C179342 IAO_0000115 "A preparation of soluble adapter molecules consisting of an antigen-binding moiety targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), linked to a peptide motif recognizable by UniCAR02-T, that may be used to activate UniCAR02-T. Upon administration of PSMA-specific targeting module (TM) TMpPSMA, and upon co-administration of UniCAR02-T, the antigen-binding moiety of TMpPSMA targets and binds to cancer cells expressing PSMA, and the binding domain of UniCAR02-T binds to the nuclear antigen motif of TMpPSMA. This activates UniCAR02-T, and induces selective toxicity in and causes lysis of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.
- NCIT_C179342 NCIT_A7 NCIT_C17796 @default.
- NCIT_C179342 NCIT_NHC0 "C179342" @default.
- NCIT_C179342 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179342 NCIT_P108 "PSMA-specific Targeting Module TMpPSMA" @default.
- NCIT_C179342 NCIT_P208 "CL1661974" @default.
- NCIT_C179342 NCIT_P322 "GDC" @default.
- NCIT_C179342 NCIT_P399 "804719" @default.
- NCIT_C179342 normalizedInformationContent "100" @default.
- NCIT_C179342 referenceCount "1" @default.
- NCIT_C179342 hasExactSynonym "PSMA Peptide Target Module TMpPSMA" @default.
- NCIT_C179342 hasExactSynonym "PSMA-specific TM TMpPSMA" @default.
- NCIT_C179342 hasExactSynonym "PSMA-specific Targeting Module TMpPSMA" @default.
- NCIT_C179342 hasExactSynonym "TMpPSMA" @default.
- NCIT_C179342 inSubset NCIT_C128784 @default.
- NCIT_C179342 inSubset NCIT_C157711 @default.
- NCIT_C179342 inSubset NCIT_C157712 @default.
- NCIT_C179342 inSubset NCIT_C176424 @default.
- NCIT_C179342 type Class @default.
- NCIT_C179342 isDefinedBy ncit.owl @default.
- NCIT_C179342 label "PSMA-specific Targeting Module TMpPSMA" @default.
- NCIT_C179342 subClassOf NCIT_C1512 @default.
- NCIT_C179342 subClassOf NCIT_C163758 @default.
- NCIT_C179342 subClassOf NCIT_C176017 @default.
- NCIT_C179342 subClassOf NCIT_C179342 @default.
- NCIT_C179342 subClassOf NCIT_C1908 @default.
- NCIT_C179342 subClassOf NCIT_C1909 @default.
- NCIT_C179342 subClassOf NCIT_C274 @default.
- NCIT_C179342 subClassOf NCIT_C307 @default.
- NCIT_C179342 subClassOf NCIT_C308 @default.