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- NCIT_C179375 IAO_0000115 "A preparation of allogeneic red blood cells (RBCs) engineered to act as artificial antigen presenting cells (aAPCs) and express on the cell surface the human papillomavirus (HPV) type 16 E7 protein on the major histocompatibility complex (MHC) I, the co-stimulatory molecule tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL) and the immunostimulatory cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon administration of the engineered RBCs expressing HPV16 E7/4-1BBL/IL-12 RTX-321, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E7. In addition, 4-1BBL and IL-12 expressed on these cells bind to 4-1BB and IL-12 receptors and subsequently induce the proliferation and activation of natural killer (NK) cells and T-cells. This enhances the secretion of cytokine interferon-gamma (IFN-g) and further induces an anti-tumor immune response. HPV16 E7 plays an important role in the development of certain types of cancer. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily (TNFRSF), is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. IL-12 promotes the activation of NK cells, which induces both the secretion of IFN-g and a CTL response against the tumor cells." @default.
- NCIT_C179375 NCIT_A7 NCIT_C1179 @default.
- NCIT_C179375 NCIT_NHC0 "C179375" @default.
- NCIT_C179375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179375 NCIT_P107 "Engineered Red Blood Cells Expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 NCIT_P108 "Engineered Red Blood Cells Expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 NCIT_P208 "CL1661942" @default.
- NCIT_C179375 NCIT_P322 "CTRP" @default.
- NCIT_C179375 NCIT_P322 "GDC" @default.
- NCIT_C179375 NCIT_P399 "804784" @default.
- NCIT_C179375 normalizedInformationContent "100" @default.
- NCIT_C179375 referenceCount "1" @default.
- NCIT_C179375 hasExactSynonym "Allogeneic Artificial Antigen-presenting Cells-expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 hasExactSynonym "Allogeneic aAPCs-expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 hasExactSynonym "Engineered RBCs Expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 hasExactSynonym "Engineered Red Blood Cells Expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 hasExactSynonym "HPV+ aAPC RTX-321" @default.
- NCIT_C179375 hasExactSynonym "RTX 321" @default.
- NCIT_C179375 hasExactSynonym "RTX-321" @default.
- NCIT_C179375 hasExactSynonym "RTX321" @default.
- NCIT_C179375 inSubset NCIT_C116977 @default.
- NCIT_C179375 inSubset NCIT_C116978 @default.
- NCIT_C179375 inSubset NCIT_C128784 @default.
- NCIT_C179375 inSubset NCIT_C157711 @default.
- NCIT_C179375 inSubset NCIT_C157712 @default.
- NCIT_C179375 inSubset NCIT_C176424 @default.
- NCIT_C179375 type Class @default.
- NCIT_C179375 isDefinedBy ncit.owl @default.
- NCIT_C179375 label "Engineered Red Blood Cells Expressing HPV16 E7/4-1BBL/IL-12 RTX-321" @default.
- NCIT_C179375 subClassOf NCIT_C179375 @default.
- NCIT_C179375 subClassOf NCIT_C1908 @default.
- NCIT_C179375 subClassOf NCIT_C1909 @default.
- NCIT_C179375 subClassOf NCIT_C307 @default.
- NCIT_C179375 subClassOf NCIT_C308 @default.