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- NCIT_C179514 IAO_0000115 "A hexamerization-enhanced human immunoglobulin G1 (IgG1) monoclonal antibody that targets the cell surface glycoprotein CD-38 and carries the E430G mutation, with potential immunomodulating and antineoplastic activities. Upon administration, erzotabart targets and binds to CD38 on CD38-positive tumor cells, thereby forming antibody hexamers through increased intermolecular Fc-Fc interactions upon antigen binding. This may trigger direct cell killing, antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cell mediated phagocytosis (ADCP) and antibody-mediated complement dependent cytotoxicity (CDC) in CD38-expressing tumor cells. In addition, binding to CD38 by GEN3014 induces downmodulation of CD38, inhibits CD38 cyclase activity, and may abrogate immune suppression in the tumor microenvironment (TME). CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies." @default.
- NCIT_C179514 NCIT_A7 NCIT_C84323 @default.
- NCIT_C179514 NCIT_NHC0 "C179514" @default.
- NCIT_C179514 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179514 NCIT_P107 "Erzotabart" @default.
- NCIT_C179514 NCIT_P108 "Erzotabart" @default.
- NCIT_C179514 NCIT_P208 "CL1662132" @default.
- NCIT_C179514 NCIT_P210 "2430792-01-9" @default.
- NCIT_C179514 NCIT_P319 "1I9AVY2IS7" @default.
- NCIT_C179514 NCIT_P322 "CTRP" @default.
- NCIT_C179514 NCIT_P322 "FDA" @default.
- NCIT_C179514 NCIT_P322 "GDC" @default.
- NCIT_C179514 NCIT_P399 "805125" @default.
- NCIT_C179514 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179514 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179514 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179514 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179514 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179514 normalizedInformationContent "100" @default.
- NCIT_C179514 referenceCount "1" @default.
- NCIT_C179514 hasExactSynonym "Anti-CD38 Monoclonal Antibody GEN3014" @default.
- NCIT_C179514 hasExactSynonym "ERZOTABART" @default.
- NCIT_C179514 hasExactSynonym "Erzotabart" @default.
- NCIT_C179514 hasExactSynonym "GEN 3014" @default.
- NCIT_C179514 hasExactSynonym "GEN-3014" @default.
- NCIT_C179514 hasExactSynonym "GEN3014" @default.
- NCIT_C179514 hasExactSynonym "HexaBody-CD38" @default.
- NCIT_C179514 inSubset NCIT_C116977 @default.
- NCIT_C179514 inSubset NCIT_C116978 @default.
- NCIT_C179514 inSubset NCIT_C128784 @default.
- NCIT_C179514 inSubset NCIT_C157711 @default.
- NCIT_C179514 inSubset NCIT_C157712 @default.
- NCIT_C179514 inSubset NCIT_C176424 @default.
- NCIT_C179514 inSubset NCIT_C63923 @default.
- NCIT_C179514 type Class @default.
- NCIT_C179514 isDefinedBy ncit.owl @default.
- NCIT_C179514 label "Erzotabart" @default.
- NCIT_C179514 subClassOf NCIT_C129821 @default.
- NCIT_C179514 subClassOf NCIT_C129822 @default.
- NCIT_C179514 subClassOf NCIT_C155321 @default.
- NCIT_C179514 subClassOf NCIT_C163758 @default.
- NCIT_C179514 subClassOf NCIT_C164008 @default.
- NCIT_C179514 subClassOf NCIT_C179514 @default.
- NCIT_C179514 subClassOf NCIT_C1908 @default.
- NCIT_C179514 subClassOf NCIT_C1909 @default.
- NCIT_C179514 subClassOf NCIT_C20401 @default.
- NCIT_C179514 subClassOf NCIT_C274 @default.
- NCIT_C179514 subClassOf NCIT_C307 @default.
- NCIT_C179514 subClassOf NCIT_C308 @default.