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- NCIT_C179563 IAO_0000115 "The tosylate salt form of remimazolam, a short-acting benzodiazepine derivative that is structurally related to midazolam, with sedative-hypnotic activity. Upon administration, remimazolam targets and binds to a specific site on the gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability." @default.
- NCIT_C179563 NCIT_A6 NCIT_C152187 @default.
- NCIT_C179563 NCIT_NHC0 "C179563" @default.
- NCIT_C179563 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179563 NCIT_P108 "Remimazolam Tosylate" @default.
- NCIT_C179563 NCIT_P208 "CL1662088" @default.
- NCIT_C179563 NCIT_P210 "1425904-79-5" @default.
- NCIT_C179563 NCIT_P319 "9J7J08A8LT" @default.
- NCIT_C179563 NCIT_P322 "FDA" @default.
- NCIT_C179563 NCIT_P399 "804909" @default.
- NCIT_C179563 normalizedInformationContent "100" @default.
- NCIT_C179563 referenceCount "1" @default.
- NCIT_C179563 hasExactSynonym "4-Methylbenzenesulfonic Acid" @default.
- NCIT_C179563 hasExactSynonym "Methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate" @default.
- NCIT_C179563 hasExactSynonym "REMIMAZOLAM TOSYLATE" @default.
- NCIT_C179563 hasExactSynonym "Remimazolam Tosylate" @default.
- NCIT_C179563 inSubset NCIT_C176424 @default.
- NCIT_C179563 inSubset NCIT_C63923 @default.
- NCIT_C179563 type Class @default.
- NCIT_C179563 isDefinedBy ncit.owl @default.
- NCIT_C179563 label "Remimazolam Tosylate" @default.
- NCIT_C179563 subClassOf NCIT_C1012 @default.
- NCIT_C179563 subClassOf NCIT_C179563 @default.
- NCIT_C179563 subClassOf NCIT_C1908 @default.
- NCIT_C179563 subClassOf NCIT_C1909 @default.
- NCIT_C179563 subClassOf NCIT_C28197 @default.
- NCIT_C179563 subClassOf NCIT_C29756 @default.
- NCIT_C179563 subClassOf NCIT_C78272 @default.