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- NCIT_C179571 IAO_0000115 "An orally bioavailable naturally occurring polyphenol found in many fruits and vegetables, with potential antioxidant, neuroprotective, anti-inflammatory, antineoplastic, senolytic, and longevity promoting activities. Upon administration, fisetin, as an antioxidant, scavenges free radicals, protect cells from oxidative stress, and is able to upregulate glutathione. It inhibits pro-inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6), and nuclear factor kappa B (NF-kB). Fisetin promotes cellular metabolism, reduces senescence, regulates sirtuin function and may promote longevity. Fisetin also exerts anti-cancer activity by inhibiting certain signaling pathways. It also inhibits certain anti-apoptotic proteins and induces apoptosis in susceptible cells." @default.
- NCIT_C179571 NCIT_NHC0 "C179571" @default.
- NCIT_C179571 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179571 NCIT_P108 "Fisetin" @default.
- NCIT_C179571 NCIT_P208 "CL1662093" @default.
- NCIT_C179571 NCIT_P210 "528-48-3" @default.
- NCIT_C179571 NCIT_P319 "OO2ABO9578" @default.
- NCIT_C179571 NCIT_P322 "FDA" @default.
- NCIT_C179571 NCIT_P322 "GDC" @default.
- NCIT_C179571 NCIT_P399 "804783" @default.
- NCIT_C179571 normalizedInformationContent "100" @default.
- NCIT_C179571 referenceCount "1" @default.
- NCIT_C179571 hasExactSynonym "3,3',4',7-Tetrahydroxyflavone" @default.
- NCIT_C179571 hasExactSynonym "7,3',4'-Flavon-3-ol" @default.
- NCIT_C179571 hasExactSynonym "FISETIN" @default.
- NCIT_C179571 hasExactSynonym "Fisetin" @default.
- NCIT_C179571 inSubset NCIT_C128784 @default.
- NCIT_C179571 inSubset NCIT_C157711 @default.
- NCIT_C179571 inSubset NCIT_C157712 @default.
- NCIT_C179571 inSubset NCIT_C176424 @default.
- NCIT_C179571 inSubset NCIT_C63923 @default.
- NCIT_C179571 type Class @default.
- NCIT_C179571 isDefinedBy ncit.owl @default.
- NCIT_C179571 label "Fisetin" @default.
- NCIT_C179571 subClassOf NCIT_C1509 @default.
- NCIT_C179571 subClassOf NCIT_C179571 @default.
- NCIT_C179571 subClassOf NCIT_C1908 @default.
- NCIT_C179571 subClassOf NCIT_C1909 @default.
- NCIT_C179571 subClassOf NCIT_C2189 @default.
- NCIT_C179571 subClassOf NCIT_C26170 @default.
- NCIT_C179571 subClassOf NCIT_C274 @default.
- NCIT_C179571 subClassOf NCIT_C275 @default.