Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C179578> ?p ?o ?g. }
Showing items 1 to 38 of
38
with 100 items per page.
- NCIT_C179578 IAO_0000115 "An orally bioavailable inhibitor of multiple kinases, including the receptor tyrosine kinases AXL (UFO) and FMS-like tyrosine kinase-3 (FLT3; CD135; fetal liver kinase-2; Flk2), and the neurotrophic tyrosine receptor kinases (NTRKs), with potential antineoplastic activity. Upon oral administration, AXL/FLT3/NTRK inhibitor HH30134 binds to and inhibits wild-type, point mutants and fusion proteins of AXL, FLT3 and NTRK. Inhibition of these kinases leads to the disruption of downstream signaling pathways and the inhibition of cell growth of tumors in which these kinases are overexpressed, rearranged or mutated. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types and also expressed in a variety of immune cells including macrophages, natural killer (NK) cells, and regulatory T-cells (Tregs). It plays a key role in tumor cell proliferation, survival, invasion and metastasis, and is a mediator of immunosuppression. Its expression is associated with drug resistance and poor prognosis. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias. TRK, a family of receptor tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes. The expression of either mutated forms of, or fusion proteins involving, NTRK family members results in uncontrolled TRK signaling, which plays an important role in tumor cell growth, survival, invasion and treatment resistance." @default.
- NCIT_C179578 NCIT_A7 NCIT_C17475 @default.
- NCIT_C179578 NCIT_A7 NCIT_C26202 @default.
- NCIT_C179578 NCIT_NHC0 "C179578" @default.
- NCIT_C179578 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179578 NCIT_P108 "AXL/FLT3/NTRK Inhibitor HH30134" @default.
- NCIT_C179578 NCIT_P208 "CL1662189" @default.
- NCIT_C179578 NCIT_P322 "GDC" @default.
- NCIT_C179578 NCIT_P399 "804914" @default.
- NCIT_C179578 normalizedInformationContent "100" @default.
- NCIT_C179578 referenceCount "1" @default.
- NCIT_C179578 hasExactSynonym "AXL/FLT3/NTRK Inhibitor HH30134" @default.
- NCIT_C179578 hasExactSynonym "HH 30134" @default.
- NCIT_C179578 hasExactSynonym "HH-30134" @default.
- NCIT_C179578 hasExactSynonym "HH30134" @default.
- NCIT_C179578 hasExactSynonym "JND30134" @default.
- NCIT_C179578 inSubset NCIT_C128784 @default.
- NCIT_C179578 inSubset NCIT_C157711 @default.
- NCIT_C179578 inSubset NCIT_C157712 @default.
- NCIT_C179578 inSubset NCIT_C176424 @default.
- NCIT_C179578 type Class @default.
- NCIT_C179578 isDefinedBy ncit.owl @default.
- NCIT_C179578 label "AXL/FLT3/NTRK Inhibitor HH30134" @default.
- NCIT_C179578 subClassOf NCIT_C124800 @default.
- NCIT_C179578 subClassOf NCIT_C129824 @default.
- NCIT_C179578 subClassOf NCIT_C129825 @default.
- NCIT_C179578 subClassOf NCIT_C1404 @default.
- NCIT_C179578 subClassOf NCIT_C155765 @default.
- NCIT_C179578 subClassOf NCIT_C163758 @default.
- NCIT_C179578 subClassOf NCIT_C163790 @default.
- NCIT_C179578 subClassOf NCIT_C179578 @default.
- NCIT_C179578 subClassOf NCIT_C1908 @default.
- NCIT_C179578 subClassOf NCIT_C1909 @default.
- NCIT_C179578 subClassOf NCIT_C1967 @default.
- NCIT_C179578 subClassOf NCIT_C200418 @default.
- NCIT_C179578 subClassOf NCIT_C2189 @default.
- NCIT_C179578 subClassOf NCIT_C274 @default.
- NCIT_C179578 subClassOf NCIT_C471 @default.