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- NCIT_C1796 IAO_0000115 "A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier." @default.
- NCIT_C1796 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1796 NCIT_A7 NCIT_C16682 @default.
- NCIT_C1796 NCIT_NHC0 "C1796" @default.
- NCIT_C1796 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1796 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1796 NCIT_P107 "Vorinostat" @default.
- NCIT_C1796 NCIT_P108 "Vorinostat" @default.
- NCIT_C1796 NCIT_P175 "701852" @default.
- NCIT_C1796 NCIT_P207 "C0672708" @default.
- NCIT_C1796 NCIT_P210 "149647-78-9" @default.
- NCIT_C1796 NCIT_P302 "Cutaneous T-cell Lymphoma" @default.
- NCIT_C1796 NCIT_P319 "58IFB293JI" @default.
- NCIT_C1796 NCIT_P322 "CTRP" @default.
- NCIT_C1796 NCIT_P322 "FDA" @default.
- NCIT_C1796 NCIT_P322 "GDC" @default.
- NCIT_C1796 NCIT_P325 "A drug that is used to treat cutaneous T-cell lymphoma that does not get better, gets worse, or comes back during or after treatment with other drugs. It is also being studied in the treatment of other types of cancer. Vorinostat is a type of histone deacetylase inhibitor." @default.
- NCIT_C1796 NCIT_P329 "37944" @default.
- NCIT_C1796 NCIT_P330 "37944" @default.
- NCIT_C1796 NCIT_P350 "C14H20N2O3" @default.
- NCIT_C1796 NCIT_P366 "Suberoylanilide_Hydroxamic_Acid" @default.
- NCIT_C1796 NCIT_P375 "Vorinostat" @default.
- NCIT_C1796 NCIT_P399 "37944" @default.
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- NCIT_C1796 NCIT_R146 NCIT_C16554 @default.
- NCIT_C1796 NCIT_R146 NCIT_C16682 @default.
- NCIT_C1796 NCIT_R146 NCIT_C16701 @default.
- NCIT_C1796 NCIT_R146 NCIT_C17021 @default.
- NCIT_C1796 NCIT_R146 NCIT_C20027 @default.
- NCIT_C1796 NCIT_R146 NCIT_C26503 @default.
- NCIT_C1796 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1796 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1796 referenceCount "2" @default.
- NCIT_C1796 hasExactSynonym "L-001079038" @default.
- NCIT_C1796 hasExactSynonym "MSK-390" @default.
- NCIT_C1796 hasExactSynonym "N-Hydroxy-N'-phenyloctanediamide" @default.
- NCIT_C1796 hasExactSynonym "SAHA" @default.
- NCIT_C1796 hasExactSynonym "Suberanilohydroxamic Acid" @default.
- NCIT_C1796 hasExactSynonym "Suberoylanilide Hydroxamic Acid" @default.
- NCIT_C1796 hasExactSynonym "VORINOSTAT" @default.
- NCIT_C1796 hasExactSynonym "Vorinostat" @default.
- NCIT_C1796 hasExactSynonym "Zolinza" @default.
- NCIT_C1796 hasExactSynonym "suberoylanilide hydroxamic acid" @default.
- NCIT_C1796 hasExactSynonym "vorinostat" @default.
- NCIT_C1796 inSubset NCIT_C116977 @default.
- NCIT_C1796 inSubset NCIT_C116978 @default.
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- NCIT_C1796 type Class @default.
- NCIT_C1796 isDefinedBy ncit.owl @default.
- NCIT_C1796 label "Vorinostat" @default.
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