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- NCIT_C179601 IAO_0000115 "An orally bioavailable pan-human epidermal growth factor receptors (EGFR; HER) tyrosine kinase inhibitor, with potential antineoplastic activity. Upon oral administration, pan-HER inhibitor FCN-411 targets, binds to and inhibits human epidermal growth factor receptors (HER) EGFR (HER1; ErbB1), HER2 (neu, ErbB-2), HER3 (ErbB-3) and HER4 (ErbB-4), and including EGFR activating and resistance mutations such as EGFR T790M/L858. This inhibits downstream signaling leading to the inhibition of proliferation of tumor cells that overexpress these receptors. EGFR family members play key roles in regulating cell proliferation and differentiation, and are overexpressed in many different tumor cell types." @default.
- NCIT_C179601 NCIT_A7 NCIT_C17068 @default.
- NCIT_C179601 NCIT_NHC0 "C179601" @default.
- NCIT_C179601 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179601 NCIT_P108 "Pan-HER Inhibitor FCN-411" @default.
- NCIT_C179601 NCIT_P208 "CL1662182" @default.
- NCIT_C179601 NCIT_P322 "GDC" @default.
- NCIT_C179601 NCIT_P399 "804791" @default.
- NCIT_C179601 normalizedInformationContent "100" @default.
- NCIT_C179601 referenceCount "1" @default.
- NCIT_C179601 hasExactSynonym "FCN 411" @default.
- NCIT_C179601 hasExactSynonym "FCN-411" @default.
- NCIT_C179601 hasExactSynonym "FCN411" @default.
- NCIT_C179601 hasExactSynonym "Pan-HER Inhibitor FCN-411" @default.
- NCIT_C179601 inSubset NCIT_C128784 @default.
- NCIT_C179601 inSubset NCIT_C157711 @default.
- NCIT_C179601 inSubset NCIT_C157712 @default.
- NCIT_C179601 inSubset NCIT_C176424 @default.
- NCIT_C179601 type Class @default.
- NCIT_C179601 isDefinedBy ncit.owl @default.
- NCIT_C179601 label "Pan-HER Inhibitor FCN-411" @default.
- NCIT_C179601 subClassOf NCIT_C1404 @default.
- NCIT_C179601 subClassOf NCIT_C163758 @default.
- NCIT_C179601 subClassOf NCIT_C163952 @default.
- NCIT_C179601 subClassOf NCIT_C179601 @default.
- NCIT_C179601 subClassOf NCIT_C1908 @default.
- NCIT_C179601 subClassOf NCIT_C1909 @default.
- NCIT_C179601 subClassOf NCIT_C1967 @default.
- NCIT_C179601 subClassOf NCIT_C2167 @default.
- NCIT_C179601 subClassOf NCIT_C274 @default.
- NCIT_C179601 subClassOf NCIT_C471 @default.