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- NCIT_C179616 IAO_0000115 "An orally available inhibitor of multiple kinases, including the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and the tropomyosin-related-kinase (tyrosine receptor kinase; TRK), with potential antineoplastic activity. Upon oral administration, TRK/ROS1/ALK inhibitor SIM1803-1A targets, binds to and inhibits wild-type, point mutants and fusion proteins of ALK, ROS1, and TRK, including fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2; TrkB), and 3 (NTRK3; TrkC). Inhibition of these kinases leads to the disruption of downstream signaling pathways and the inhibition of cell growth of tumors in which these kinases are overexpressed, rearranged or mutated. TRK, a family of receptor tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes. The expression of either mutated forms of, or fusion proteins involving, NTRK family members results in uncontrolled TRK signaling, which plays an important role in tumor cell growth, survival, invasion and treatment resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells." @default.
- NCIT_C179616 NCIT_A7 NCIT_C17691 @default.
- NCIT_C179616 NCIT_A7 NCIT_C27032 @default.
- NCIT_C179616 NCIT_NHC0 "C179616" @default.
- NCIT_C179616 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179616 NCIT_P108 "TRK/ROS1/ALK Inhibitor SIM1803-1A" @default.
- NCIT_C179616 NCIT_P208 "CL1662160" @default.
- NCIT_C179616 NCIT_P322 "GDC" @default.
- NCIT_C179616 NCIT_P399 "804807" @default.
- NCIT_C179616 normalizedInformationContent "100" @default.
- NCIT_C179616 referenceCount "1" @default.
- NCIT_C179616 hasExactSynonym "SIM1803 1A" @default.
- NCIT_C179616 hasExactSynonym "SIM1803-1A" @default.
- NCIT_C179616 hasExactSynonym "SIM18031A" @default.
- NCIT_C179616 hasExactSynonym "TRK/ROS1/ALK Inhibitor SIM1803-1A" @default.
- NCIT_C179616 inSubset NCIT_C128784 @default.
- NCIT_C179616 inSubset NCIT_C157711 @default.
- NCIT_C179616 inSubset NCIT_C157712 @default.
- NCIT_C179616 inSubset NCIT_C176424 @default.
- NCIT_C179616 type Class @default.
- NCIT_C179616 isDefinedBy ncit.owl @default.
- NCIT_C179616 label "TRK/ROS1/ALK Inhibitor SIM1803-1A" @default.
- NCIT_C179616 subClassOf NCIT_C129824 @default.
- NCIT_C179616 subClassOf NCIT_C129825 @default.
- NCIT_C179616 subClassOf NCIT_C1404 @default.
- NCIT_C179616 subClassOf NCIT_C141136 @default.
- NCIT_C179616 subClassOf NCIT_C163758 @default.
- NCIT_C179616 subClassOf NCIT_C179616 @default.
- NCIT_C179616 subClassOf NCIT_C1908 @default.
- NCIT_C179616 subClassOf NCIT_C1909 @default.
- NCIT_C179616 subClassOf NCIT_C1967 @default.
- NCIT_C179616 subClassOf NCIT_C2189 @default.
- NCIT_C179616 subClassOf NCIT_C274 @default.
- NCIT_C179616 subClassOf NCIT_C471 @default.