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- NCIT_C179617 IAO_0000115 "A depot formulation containing the decanoate ester of abiraterone, a steroidal compound with antiandrogen activity. Upon administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This suppresses testosterone production by both the testes and the adrenals to castrate-range levels. This may decrease androgen-dependent growth signaling and inhibit the proliferation of androgen-dependent tumor cells." @default.
- NCIT_C179617 NCIT_A7 NCIT_C40068 @default.
- NCIT_C179617 NCIT_NHC0 "C179617" @default.
- NCIT_C179617 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179617 NCIT_P107 "Abiraterone Decanoate Depot" @default.
- NCIT_C179617 NCIT_P108 "Abiraterone Decanoate Depot" @default.
- NCIT_C179617 NCIT_P208 "CL1662159" @default.
- NCIT_C179617 NCIT_P322 "CTRP" @default.
- NCIT_C179617 NCIT_P322 "GDC" @default.
- NCIT_C179617 NCIT_P399 "804911" @default.
- NCIT_C179617 normalizedInformationContent "100" @default.
- NCIT_C179617 referenceCount "1" @default.
- NCIT_C179617 hasExactSynonym "Abiraterone Decanoate Depot" @default.
- NCIT_C179617 hasExactSynonym "PRL 02" @default.
- NCIT_C179617 hasExactSynonym "PRL-02 Depot" @default.
- NCIT_C179617 hasExactSynonym "PRL-02" @default.
- NCIT_C179617 hasExactSynonym "PRL02" @default.
- NCIT_C179617 inSubset NCIT_C116977 @default.
- NCIT_C179617 inSubset NCIT_C116978 @default.
- NCIT_C179617 inSubset NCIT_C128784 @default.
- NCIT_C179617 inSubset NCIT_C157711 @default.
- NCIT_C179617 inSubset NCIT_C157712 @default.
- NCIT_C179617 inSubset NCIT_C176424 @default.
- NCIT_C179617 type Class @default.
- NCIT_C179617 isDefinedBy ncit.owl @default.
- NCIT_C179617 label "Abiraterone Decanoate Depot" @default.
- NCIT_C179617 subClassOf NCIT_C147908 @default.
- NCIT_C179617 subClassOf NCIT_C147923 @default.
- NCIT_C179617 subClassOf NCIT_C179617 @default.
- NCIT_C179617 subClassOf NCIT_C1908 @default.
- NCIT_C179617 subClassOf NCIT_C1909 @default.
- NCIT_C179617 subClassOf NCIT_C242 @default.
- NCIT_C179617 subClassOf NCIT_C471 @default.
- NCIT_C179617 subClassOf NCIT_C547 @default.