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- NCIT_C179620 IAO_0000115 "A lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding for a monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, mRNA-encoded anti-claudin18.2 monoclonal antibody BNT141 binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is then translated by ribosomes to produce the anti-CLDN18.2 monoclonal antibody. The antibody specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C179620 NCIT_A7 NCIT_C150412 @default.
- NCIT_C179620 NCIT_NHC0 "C179620" @default.
- NCIT_C179620 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179620 NCIT_P108 "mRNA-encoded Anti-Claudin18.2 Monoclonal Antibody BNT141" @default.
- NCIT_C179620 NCIT_P208 "CL1662171" @default.
- NCIT_C179620 NCIT_P322 "GDC" @default.
- NCIT_C179620 NCIT_P399 "804814" @default.
- NCIT_C179620 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179620 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179620 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179620 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179620 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179620 normalizedInformationContent "100" @default.
- NCIT_C179620 referenceCount "1" @default.
- NCIT_C179620 hasExactSynonym "Anti-CLDN18.2 mRNA-encoded Antibody BNT141" @default.
- NCIT_C179620 hasExactSynonym "BNT 141" @default.
- NCIT_C179620 hasExactSynonym "BNT-141" @default.
- NCIT_C179620 hasExactSynonym "BNT141" @default.
- NCIT_C179620 hasExactSynonym "RiboMab BNT141" @default.
- NCIT_C179620 hasExactSynonym "mRNA-encoded Anti-Claudin18.2 Monoclonal Antibody BNT141" @default.
- NCIT_C179620 hasExactSynonym "mRNA-encoded Antibody BNT141" @default.
- NCIT_C179620 hasExactSynonym "rMAB BNT141" @default.
- NCIT_C179620 inSubset NCIT_C128784 @default.
- NCIT_C179620 inSubset NCIT_C157711 @default.
- NCIT_C179620 inSubset NCIT_C157712 @default.
- NCIT_C179620 inSubset NCIT_C176424 @default.
- NCIT_C179620 type Class @default.
- NCIT_C179620 isDefinedBy ncit.owl @default.
- NCIT_C179620 label "mRNA-encoded Anti-Claudin18.2 Monoclonal Antibody BNT141" @default.
- NCIT_C179620 subClassOf NCIT_C129821 @default.
- NCIT_C179620 subClassOf NCIT_C129822 @default.
- NCIT_C179620 subClassOf NCIT_C163758 @default.
- NCIT_C179620 subClassOf NCIT_C179620 @default.
- NCIT_C179620 subClassOf NCIT_C179676 @default.
- NCIT_C179620 subClassOf NCIT_C1908 @default.
- NCIT_C179620 subClassOf NCIT_C1909 @default.
- NCIT_C179620 subClassOf NCIT_C200250 @default.
- NCIT_C179620 subClassOf NCIT_C20401 @default.
- NCIT_C179620 subClassOf NCIT_C274 @default.
- NCIT_C179620 subClassOf NCIT_C307 @default.
- NCIT_C179620 subClassOf NCIT_C308 @default.