Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C179621> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C179621 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2) and the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunostimulating and antineoplastic activities. Upon administration, anti-HER2/anti-PD-L1 CAR T-cells target and bind to HER2- and PD-L1-expressing tumor cells, thereby inducing selective toxicity in HER2- and PD-L1-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. PD-L1 is overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity." @default.
- NCIT_C179621 NCIT_A7 NCIT_C17319 @default.
- NCIT_C179621 NCIT_A7 NCIT_C96024 @default.
- NCIT_C179621 NCIT_NHC0 "C179621" @default.
- NCIT_C179621 NCIT_P106 "Cell" @default.
- NCIT_C179621 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179621 NCIT_P107 "HER-2/PD-L1-targeting CAR-T Cells" @default.
- NCIT_C179621 NCIT_P108 "HER-2/PD-L1-targeting CAR-T Cells" @default.
- NCIT_C179621 NCIT_P208 "CL1662170" @default.
- NCIT_C179621 NCIT_P322 "CTRP" @default.
- NCIT_C179621 NCIT_P399 "804815" @default.
- NCIT_C179621 normalizedInformationContent "100" @default.
- NCIT_C179621 referenceCount "1" @default.
- NCIT_C179621 hasExactSynonym "Anti-HER2/anti-PD-L1 CAR T Cells" @default.
- NCIT_C179621 hasExactSynonym "Dual-targeting HER2 and PD-L1 CAR-T Cells" @default.
- NCIT_C179621 hasExactSynonym "HER-2/PD-L1-targeting CAR-T Cells" @default.
- NCIT_C179621 inSubset NCIT_C116977 @default.
- NCIT_C179621 inSubset NCIT_C116978 @default.
- NCIT_C179621 inSubset NCIT_C128784 @default.
- NCIT_C179621 inSubset NCIT_C176424 @default.
- NCIT_C179621 type Class @default.
- NCIT_C179621 isDefinedBy ncit.owl @default.
- NCIT_C179621 label "HER-2/PD-L1-targeting CAR-T Cells" @default.
- NCIT_C179621 subClassOf NCIT_C137999 @default.
- NCIT_C179621 subClassOf NCIT_C142078 @default.
- NCIT_C179621 subClassOf NCIT_C154231 @default.
- NCIT_C179621 subClassOf NCIT_C179621 @default.
- NCIT_C179621 subClassOf NCIT_C1908 @default.
- NCIT_C179621 subClassOf NCIT_C1909 @default.
- NCIT_C179621 subClassOf NCIT_C1962 @default.
- NCIT_C179621 subClassOf NCIT_C201497 @default.
- NCIT_C179621 subClassOf NCIT_C307 @default.
- NCIT_C179621 subClassOf NCIT_C308 @default.