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- NCIT_C179622 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) coupled to the co-immunostimulatory signaling domain 4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain (CD3z), which is needed for TCR signaling, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR T cells KD-025 specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs), resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells. NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell types, but are not expressed on most normal, healthy cells." @default.
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- NCIT_C179622 hasExactSynonym "Autologous CAR-T Cells KD-025" @default.
- NCIT_C179622 hasExactSynonym "Autologous NKG2D CAR T Cells KD-025" @default.
- NCIT_C179622 hasExactSynonym "KD 025" @default.
- NCIT_C179622 hasExactSynonym "KD-025" @default.
- NCIT_C179622 hasExactSynonym "KD025" @default.
- NCIT_C179622 hasExactSynonym "NKG2D-specific CAR-T Cells KD-025" @default.
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- NCIT_C179622 label "Autologous NKG2D CAR T Cells KD-025" @default.
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