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- NCIT_C179623 IAO_0000115 "An oncolytic vaccinia virus (VV; VACV) genetically engineered to express 4-E03, an immunoglobulin G1 (IgG1) antibody directed against the human inhibitory T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4) and the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential oncolytic, immunostimulating and antineoplastic activities. Upon intra-tumoral administration, the oncolytic VV expressing anti-CTLA-4 antibody and GM-CSF BT-001 specifically infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. In addition, oncolytic virus BT-001 promotes the secretion of anti-CTLA-4 antibody 4-E03 and GM-CSF by the tumor cells. GM-CSF attracts dendritic cells (DCs) and may further stimulate a CTL-mediated immune response against tumor cells. Anti-CTLA-4 antibody 4-E03 targets and binds to CTLA-4 expressed on T-cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This enhances the CTL-mediated immune response against tumor cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C179623 NCIT_NHC0 "C179623" @default.
- NCIT_C179623 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179623 NCIT_P108 "Oncolytic Vaccinia Virus Expressing Anti-CTLA-4 Antibody and GM-CSF BT-001" @default.
- NCIT_C179623 NCIT_P208 "CL1662165" @default.
- NCIT_C179623 NCIT_P322 "GDC" @default.
- NCIT_C179623 NCIT_P399 "804920" @default.
- NCIT_C179623 normalizedInformationContent "100" @default.
- NCIT_C179623 referenceCount "1" @default.
- NCIT_C179623 hasExactSynonym "BT 001" @default.
- NCIT_C179623 hasExactSynonym "BT-001" @default.
- NCIT_C179623 hasExactSynonym "BT001" @default.
- NCIT_C179623 hasExactSynonym "Oncolytic VV Expressing Anti-CTLA4 Antibody and GM-CSF BT-001" @default.
- NCIT_C179623 hasExactSynonym "Oncolytic Vaccinia Virus Expressing Anti-CTLA-4 Antibody and GM-CSF BT-001" @default.
- NCIT_C179623 hasExactSynonym "TG 6030" @default.
- NCIT_C179623 hasExactSynonym "TG-6030" @default.
- NCIT_C179623 hasExactSynonym "TG6030" @default.
- NCIT_C179623 inSubset NCIT_C128784 @default.
- NCIT_C179623 inSubset NCIT_C157711 @default.
- NCIT_C179623 inSubset NCIT_C157712 @default.
- NCIT_C179623 inSubset NCIT_C176424 @default.
- NCIT_C179623 type Class @default.
- NCIT_C179623 isDefinedBy ncit.owl @default.
- NCIT_C179623 label "Oncolytic Vaccinia Virus Expressing Anti-CTLA-4 Antibody and GM-CSF BT-001" @default.
- NCIT_C179623 subClassOf NCIT_C129821 @default.
- NCIT_C179623 subClassOf NCIT_C179623 @default.
- NCIT_C179623 subClassOf NCIT_C1908 @default.
- NCIT_C179623 subClassOf NCIT_C1909 @default.
- NCIT_C179623 subClassOf NCIT_C1962 @default.
- NCIT_C179623 subClassOf NCIT_C2139 @default.
- NCIT_C179623 subClassOf NCIT_C274 @default.
- NCIT_C179623 subClassOf NCIT_C307 @default.
- NCIT_C179623 subClassOf NCIT_C308 @default.
- NCIT_C179623 subClassOf NCIT_C717 @default.