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- NCIT_C179626 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) monoclonal antibody against C-C-chemokine receptor 7 (CCR7), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR7 monoclonal antibody CAP-100 targets and binds to CCR7 on tumor cells, and neutralizes ligand-mediated signaling through both ligands CCL19 and CCL21. This prevents the activity of CCR7 on tumor cells. CAP-100 is expected to prevent the migration of tumor cells to and their survival in lymphoid niches. In addition, CAP-100 eliminates CCR7-positive tumor cells via the induction of Fc-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). CCR7, a G-protein coupled receptor involved in trafficking of cells to lymph nodes, is normally expressed by subsets of immune cells and overexpressed in various types of cancer cells, such as in many hematological malignancies. Its overexpression has been associated with lymph node metastasis and poor survival." @default.
- NCIT_C179626 NCIT_A7 NCIT_C104130 @default.
- NCIT_C179626 NCIT_NHC0 "C179626" @default.
- NCIT_C179626 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C179626 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179626 NCIT_P108 "Anti-CCR7 Monoclonal Antibody CAP-100" @default.
- NCIT_C179626 NCIT_P207 "C0599673" @default.
- NCIT_C179626 NCIT_P322 "GDC" @default.
- NCIT_C179626 NCIT_P399 "804834" @default.
- NCIT_C179626 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179626 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179626 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179626 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179626 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179626 normalizedInformationContent "100" @default.
- NCIT_C179626 referenceCount "1" @default.
- NCIT_C179626 hasExactSynonym "Anti-CCR7 Monoclonal Antibody CAP-100" @default.
- NCIT_C179626 hasExactSynonym "CAP 100" @default.
- NCIT_C179626 hasExactSynonym "CAP-100" @default.
- NCIT_C179626 hasExactSynonym "CAP100" @default.
- NCIT_C179626 inSubset NCIT_C128784 @default.
- NCIT_C179626 inSubset NCIT_C157711 @default.
- NCIT_C179626 inSubset NCIT_C157712 @default.
- NCIT_C179626 inSubset NCIT_C176424 @default.
- NCIT_C179626 type Class @default.
- NCIT_C179626 isDefinedBy ncit.owl @default.
- NCIT_C179626 label "Anti-CCR7 Monoclonal Antibody CAP-100" @default.
- NCIT_C179626 subClassOf NCIT_C129821 @default.
- NCIT_C179626 subClassOf NCIT_C129822 @default.
- NCIT_C179626 subClassOf NCIT_C179626 @default.
- NCIT_C179626 subClassOf NCIT_C1908 @default.
- NCIT_C179626 subClassOf NCIT_C1909 @default.
- NCIT_C179626 subClassOf NCIT_C20401 @default.
- NCIT_C179626 subClassOf NCIT_C274 @default.
- NCIT_C179626 subClassOf NCIT_C307 @default.
- NCIT_C179626 subClassOf NCIT_C308 @default.