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- NCIT_C179627 IAO_0000115 "An orally bioavailable, selective pan-tropomyosin-related-kinase (tyrosine receptor kinase; TRK) inhibitor, with potential antineoplastic activity. Upon oral administration, pan-TRK inhibitor ICP-723 specifically targets and binds to TRK, TRK mutations and fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2; TrkB), and 3 (NTRK3; TrkC). This inhibits neurotrophin-TRK interaction and TRK activation, thereby preventing the activation of downstream signaling pathways and resulting in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress TRK and/or express NTRK fusion proteins. TRK, a family of receptor tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes. The expression of either mutated forms of, or fusion proteins involving, NTRK family members results in uncontrolled TRK signaling, which plays an important role in tumor cell growth, survival, invasion and treatment resistance." @default.
- NCIT_C179627 NCIT_A7 NCIT_C28558 @default.
- NCIT_C179627 NCIT_A7 NCIT_C33983 @default.
- NCIT_C179627 NCIT_A7 NCIT_C33984 @default.
- NCIT_C179627 NCIT_NHC0 "C179627" @default.
- NCIT_C179627 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179627 NCIT_P107 "Pan-TRK Inhibitor ICP-723" @default.
- NCIT_C179627 NCIT_P108 "Pan-TRK Inhibitor ICP-723" @default.
- NCIT_C179627 NCIT_P208 "CL1662146" @default.
- NCIT_C179627 NCIT_P322 "CTRP" @default.
- NCIT_C179627 NCIT_P322 "GDC" @default.
- NCIT_C179627 NCIT_P399 "804835" @default.
- NCIT_C179627 normalizedInformationContent "100" @default.
- NCIT_C179627 referenceCount "1" @default.
- NCIT_C179627 hasExactSynonym "ICP 723" @default.
- NCIT_C179627 hasExactSynonym "ICP-723" @default.
- NCIT_C179627 hasExactSynonym "ICP723" @default.
- NCIT_C179627 hasExactSynonym "Pan-TRK Inhibitor ICP-723" @default.
- NCIT_C179627 hasExactSynonym "TRK Inhibitor ICP723" @default.
- NCIT_C179627 inSubset NCIT_C116977 @default.
- NCIT_C179627 inSubset NCIT_C116978 @default.
- NCIT_C179627 inSubset NCIT_C128784 @default.
- NCIT_C179627 inSubset NCIT_C157711 @default.
- NCIT_C179627 inSubset NCIT_C157712 @default.
- NCIT_C179627 inSubset NCIT_C176424 @default.
- NCIT_C179627 type Class @default.
- NCIT_C179627 isDefinedBy ncit.owl @default.
- NCIT_C179627 label "Pan-TRK Inhibitor ICP-723" @default.
- NCIT_C179627 subClassOf NCIT_C129824 @default.
- NCIT_C179627 subClassOf NCIT_C129825 @default.
- NCIT_C179627 subClassOf NCIT_C1404 @default.
- NCIT_C179627 subClassOf NCIT_C155765 @default.
- NCIT_C179627 subClassOf NCIT_C163758 @default.
- NCIT_C179627 subClassOf NCIT_C179627 @default.
- NCIT_C179627 subClassOf NCIT_C1908 @default.
- NCIT_C179627 subClassOf NCIT_C1909 @default.
- NCIT_C179627 subClassOf NCIT_C1967 @default.
- NCIT_C179627 subClassOf NCIT_C2189 @default.
- NCIT_C179627 subClassOf NCIT_C274 @default.
- NCIT_C179627 subClassOf NCIT_C471 @default.