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- NCIT_C179628 IAO_0000115 "An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic and anti-fibrotic activities. Upon oral administration, BET inhibitor JAB-8263 targets and binds to bromodomain-containing proteins 2, 3, and 4 (BRD2, BRD3, and BRD4) as well as bromodomain testis-specific protein (BRDT), thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and suppresses the expression of certain oncogenes and profibrotic genes, including Myc and other transcriptional regulators. Preventing the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth and fibrosis. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth." @default.
- NCIT_C179628 NCIT_A7 NCIT_C106463 @default.
- NCIT_C179628 NCIT_A7 NCIT_C21376 @default.
- NCIT_C179628 NCIT_A7 NCIT_C92704 @default.
- NCIT_C179628 NCIT_A7 NCIT_C97399 @default.
- NCIT_C179628 NCIT_NHC0 "C179628" @default.
- NCIT_C179628 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179628 NCIT_P108 "BET Inhibitor JAB-8263" @default.
- NCIT_C179628 NCIT_P208 "CL1662149" @default.
- NCIT_C179628 NCIT_P322 "GDC" @default.
- NCIT_C179628 NCIT_P399 "804836" @default.
- NCIT_C179628 normalizedInformationContent "100" @default.
- NCIT_C179628 referenceCount "1" @default.
- NCIT_C179628 hasExactSynonym "BET Inhibitor JAB-8263" @default.
- NCIT_C179628 hasExactSynonym "JAB 8263" @default.
- NCIT_C179628 hasExactSynonym "JAB8-263" @default.
- NCIT_C179628 hasExactSynonym "JAB8263" @default.
- NCIT_C179628 inSubset NCIT_C128784 @default.
- NCIT_C179628 inSubset NCIT_C157711 @default.
- NCIT_C179628 inSubset NCIT_C157712 @default.
- NCIT_C179628 inSubset NCIT_C176424 @default.
- NCIT_C179628 type Class @default.
- NCIT_C179628 isDefinedBy ncit.owl @default.
- NCIT_C179628 label "BET Inhibitor JAB-8263" @default.
- NCIT_C179628 subClassOf NCIT_C128462 @default.
- NCIT_C179628 subClassOf NCIT_C129824 @default.
- NCIT_C179628 subClassOf NCIT_C179628 @default.
- NCIT_C179628 subClassOf NCIT_C1908 @default.
- NCIT_C179628 subClassOf NCIT_C1909 @default.
- NCIT_C179628 subClassOf NCIT_C2189 @default.
- NCIT_C179628 subClassOf NCIT_C274 @default.