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- NCIT_C179632 IAO_0000115 "A tetravalent, bispecific antibody directed against both the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-BCMA/anti-CD3 bispecific antibody EMB-06 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a receptor for a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. In EMB-06, the two antigen-binding fragments (Fabs) are fused directly in a crisscross orientation resulting in four active and independent antigen binding sites." @default.
- NCIT_C179632 NCIT_A7 NCIT_C97848 @default.
- NCIT_C179632 NCIT_NHC0 "C179632" @default.
- NCIT_C179632 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179632 NCIT_P108 "Anti-BCMA/Anti-CD3 Bispecific Antibody EMB-06" @default.
- NCIT_C179632 NCIT_P208 "CL1662145" @default.
- NCIT_C179632 NCIT_P322 "GDC" @default.
- NCIT_C179632 NCIT_P399 "804926" @default.
- NCIT_C179632 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179632 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179632 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179632 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179632 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179632 normalizedInformationContent "100" @default.
- NCIT_C179632 referenceCount "1" @default.
- NCIT_C179632 hasExactSynonym "Anti-BCMA/Anti-CD3 Bispecific Antibody EMB-06" @default.
- NCIT_C179632 hasExactSynonym "Anti-BCMA/Anti-CD3 FIT-Ig Bispecific Antibody EMB-06" @default.
- NCIT_C179632 hasExactSynonym "Anti-BCMA/CD3 Bispecific Antibody EMB-06" @default.
- NCIT_C179632 hasExactSynonym "BCMAxCD3 Bispecific Antibody EMB-06" @default.
- NCIT_C179632 hasExactSynonym "EMB 06" @default.
- NCIT_C179632 hasExactSynonym "EMB-06" @default.
- NCIT_C179632 hasExactSynonym "EMB06" @default.
- NCIT_C179632 hasExactSynonym "Fabs-In-Tandem Immunoglobulin Bispecific Antibody EMB-06" @default.
- NCIT_C179632 inSubset NCIT_C128784 @default.
- NCIT_C179632 inSubset NCIT_C157711 @default.
- NCIT_C179632 inSubset NCIT_C157712 @default.
- NCIT_C179632 inSubset NCIT_C176424 @default.
- NCIT_C179632 type Class @default.
- NCIT_C179632 isDefinedBy ncit.owl @default.
- NCIT_C179632 label "Anti-BCMA/Anti-CD3 Bispecific Antibody EMB-06" @default.
- NCIT_C179632 subClassOf NCIT_C112883 @default.
- NCIT_C179632 subClassOf NCIT_C129821 @default.
- NCIT_C179632 subClassOf NCIT_C129822 @default.
- NCIT_C179632 subClassOf NCIT_C1454 @default.
- NCIT_C179632 subClassOf NCIT_C163758 @default.
- NCIT_C179632 subClassOf NCIT_C179632 @default.
- NCIT_C179632 subClassOf NCIT_C181111 @default.
- NCIT_C179632 subClassOf NCIT_C181113 @default.
- NCIT_C179632 subClassOf NCIT_C181114 @default.
- NCIT_C179632 subClassOf NCIT_C1908 @default.
- NCIT_C179632 subClassOf NCIT_C1909 @default.
- NCIT_C179632 subClassOf NCIT_C201282 @default.
- NCIT_C179632 subClassOf NCIT_C20401 @default.
- NCIT_C179632 subClassOf NCIT_C274 @default.
- NCIT_C179632 subClassOf NCIT_C28227 @default.
- NCIT_C179632 subClassOf NCIT_C307 @default.
- NCIT_C179632 subClassOf NCIT_C308 @default.