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- NCIT_C179633 IAO_0000115 "A bispecific antibody targeting both the human negative immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-PD-1/anti-4-1BB bispecific antibody IBI-319 simultaneously targets and binds to PD-1, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes in the tumor microenvironment (TME), and 4-1BB, which is expressed on activated T-lymphocytes and natural killer (NK) cells. This crosslinks PD-1- and 4-1BB-expressing T cells. Through 4-1BB binding, IBI-319 acts as a conditional 4-1BB agonist, resulting in T-cell co-stimulation and enhances T-lymphocyte-mediated anti-tumor activity. At the same time, PD-1 binding prevents PD-L1 from binding to and activating its receptor PD-1 and inhibits the PD-L1/PD-1-mediated downregulation of T-cell activation and proliferation. This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C179633 NCIT_A7 NCIT_C105113 @default.
- NCIT_C179633 NCIT_A7 NCIT_C94697 @default.
- NCIT_C179633 NCIT_NHC0 "C179633" @default.
- NCIT_C179633 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179633 NCIT_P108 "Anti-PD-1/Anti-4-1BB Bispecific Antibody IBI-319" @default.
- NCIT_C179633 NCIT_P208 "CL1662144" @default.
- NCIT_C179633 NCIT_P322 "GDC" @default.
- NCIT_C179633 NCIT_P399 "800843" @default.
- NCIT_C179633 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179633 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179633 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179633 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179633 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179633 normalizedInformationContent "100" @default.
- NCIT_C179633 referenceCount "1" @default.
- NCIT_C179633 hasExactSynonym "Anti-PD-1/Anti-4-1BB Bispecific Antibody IBI-319" @default.
- NCIT_C179633 hasExactSynonym "IBI 319" @default.
- NCIT_C179633 hasExactSynonym "IBI-319" @default.
- NCIT_C179633 hasExactSynonym "IBI319" @default.
- NCIT_C179633 inSubset NCIT_C128784 @default.
- NCIT_C179633 inSubset NCIT_C157711 @default.
- NCIT_C179633 inSubset NCIT_C157712 @default.
- NCIT_C179633 inSubset NCIT_C176424 @default.
- NCIT_C179633 type Class @default.
- NCIT_C179633 isDefinedBy ncit.owl @default.
- NCIT_C179633 label "Anti-PD-1/Anti-4-1BB Bispecific Antibody IBI-319" @default.
- NCIT_C179633 subClassOf NCIT_C129821 @default.
- NCIT_C179633 subClassOf NCIT_C129822 @default.
- NCIT_C179633 subClassOf NCIT_C141144 @default.
- NCIT_C179633 subClassOf NCIT_C143250 @default.
- NCIT_C179633 subClassOf NCIT_C1454 @default.
- NCIT_C179633 subClassOf NCIT_C179633 @default.
- NCIT_C179633 subClassOf NCIT_C1908 @default.
- NCIT_C179633 subClassOf NCIT_C1909 @default.
- NCIT_C179633 subClassOf NCIT_C20401 @default.
- NCIT_C179633 subClassOf NCIT_C274 @default.
- NCIT_C179633 subClassOf NCIT_C28227 @default.
- NCIT_C179633 subClassOf NCIT_C307 @default.
- NCIT_C179633 subClassOf NCIT_C308 @default.