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- NCIT_C179635 IAO_0000115 "A tetravalent immunoglobulin G1 (IgG1) bispecific antibody targeting both the human programmed death-ligand 1 (PD-L1) and CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-CD137/PD-L1 bispecific antibody FS222 simultaneously targets and binds to CD137, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes, and PD-L1 expressed on tumor cells, thereby crosslinking PD-L1-expressing tumor cells and T-lymphocytes. Through CD137 binding, FS222 acts as a conditional CD137 agonist, resulting in T-cell co-stimulation and enhanced anti-tumor activity. At the same time, FS222 prevents PD-L1 from binding to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. Crosslinking of PD-L1-expressing tumor cells and activated T-lymphocytes may enhance T-lymphocyte-mediated lysis of PD-L1-expressing tumor cells." @default.
- NCIT_C179635 NCIT_A7 NCIT_C96024 @default.
- NCIT_C179635 NCIT_NHC0 "C179635" @default.
- NCIT_C179635 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179635 NCIT_P108 "Anti-CD137/PD-L1 Bispecific Antibody FS222" @default.
- NCIT_C179635 NCIT_P208 "CL1662154" @default.
- NCIT_C179635 NCIT_P322 "GDC" @default.
- NCIT_C179635 NCIT_P399 "804928" @default.
- NCIT_C179635 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179635 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179635 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179635 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179635 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179635 normalizedInformationContent "100" @default.
- NCIT_C179635 referenceCount "1" @default.
- NCIT_C179635 hasExactSynonym "Anti-CD137/Anti-PD-L1 Bispecific Antibody FS222" @default.
- NCIT_C179635 hasExactSynonym "Anti-CD137/PD-L1 Bispecific Antibody FS222" @default.
- NCIT_C179635 hasExactSynonym "Anti-PD-L1/Anti-4-1BB Bispecific Antibody FS222" @default.
- NCIT_C179635 hasExactSynonym "CD137xPD-L1 Bispecific Antibody FS222" @default.
- NCIT_C179635 hasExactSynonym "FS 222" @default.
- NCIT_C179635 hasExactSynonym "FS-222" @default.
- NCIT_C179635 hasExactSynonym "FS222" @default.
- NCIT_C179635 inSubset NCIT_C128784 @default.
- NCIT_C179635 inSubset NCIT_C157711 @default.
- NCIT_C179635 inSubset NCIT_C157712 @default.
- NCIT_C179635 inSubset NCIT_C176424 @default.
- NCIT_C179635 type Class @default.
- NCIT_C179635 isDefinedBy ncit.owl @default.
- NCIT_C179635 label "Anti-CD137/PD-L1 Bispecific Antibody FS222" @default.
- NCIT_C179635 subClassOf NCIT_C129821 @default.
- NCIT_C179635 subClassOf NCIT_C129822 @default.
- NCIT_C179635 subClassOf NCIT_C141144 @default.
- NCIT_C179635 subClassOf NCIT_C143250 @default.
- NCIT_C179635 subClassOf NCIT_C1454 @default.
- NCIT_C179635 subClassOf NCIT_C179635 @default.
- NCIT_C179635 subClassOf NCIT_C1908 @default.
- NCIT_C179635 subClassOf NCIT_C1909 @default.
- NCIT_C179635 subClassOf NCIT_C20401 @default.
- NCIT_C179635 subClassOf NCIT_C274 @default.
- NCIT_C179635 subClassOf NCIT_C28227 @default.
- NCIT_C179635 subClassOf NCIT_C307 @default.
- NCIT_C179635 subClassOf NCIT_C308 @default.