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- NCIT_C179638 IAO_0000115 "A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating activity. Upon administration, ribocytokine IL-2 BNT153 is taken up by cells and the expressed IL-2 targets and binds to the IL-2 receptor beta subunit (IL2Rb; IL2Rbeta; CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling, which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses against tumor cells causes tumor cell destruction. IL2Rb plays a key role in the proliferation and activation of effector T-cells." @default.
- NCIT_C179638 NCIT_A7 NCIT_C26267 @default.
- NCIT_C179638 NCIT_NHC0 "C179638" @default.
- NCIT_C179638 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C179638 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C179638 NCIT_P108 "Ribocytokine IL-2 BNT153" @default.
- NCIT_C179638 NCIT_P208 "CL1662151" @default.
- NCIT_C179638 NCIT_P322 "GDC" @default.
- NCIT_C179638 NCIT_P399 "804872" @default.
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- NCIT_C179638 NCIT_R125 NCIT_C18081 @default.
- NCIT_C179638 NCIT_R125 NCIT_C18095 @default.
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- NCIT_C179638 NCIT_R125 NCIT_C26280 @default.
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- NCIT_C179638 NCIT_R125 NCIT_C40767 @default.
- NCIT_C179638 NCIT_R125 NCIT_C40833 @default.
- NCIT_C179638 NCIT_R125 NCIT_C40912 @default.
- NCIT_C179638 NCIT_R146 NCIT_C104679 @default.
- NCIT_C179638 NCIT_R146 NCIT_C21176 @default.
- NCIT_C179638 NCIT_R146 NCIT_C26548 @default.
- NCIT_C179638 normalizedInformationContent "100" @default.
- NCIT_C179638 referenceCount "1" @default.
- NCIT_C179638 hasExactSynonym "BNT 153" @default.
- NCIT_C179638 hasExactSynonym "BNT-153" @default.
- NCIT_C179638 hasExactSynonym "BNT153" @default.
- NCIT_C179638 hasExactSynonym "Human Interleukin-2 mRNA-encoded BNT153" @default.
- NCIT_C179638 hasExactSynonym "Ribocytokine IL-2 BNT153" @default.
- NCIT_C179638 inSubset NCIT_C128784 @default.
- NCIT_C179638 inSubset NCIT_C157711 @default.
- NCIT_C179638 inSubset NCIT_C157712 @default.
- NCIT_C179638 inSubset NCIT_C176424 @default.
- NCIT_C179638 type Class @default.
- NCIT_C179638 isDefinedBy ncit.owl @default.
- NCIT_C179638 label "Ribocytokine IL-2 BNT153" @default.
- NCIT_C179638 subClassOf NCIT_C1283 @default.
- NCIT_C179638 subClassOf NCIT_C179638 @default.
- NCIT_C179638 subClassOf NCIT_C1908 @default.
- NCIT_C179638 subClassOf NCIT_C1909 @default.
- NCIT_C179638 subClassOf NCIT_C307 @default.
- NCIT_C179638 subClassOf NCIT_C308 @default.
- NCIT_C179638 subClassOf NCIT_C587 @default.
- NCIT_C179638 subClassOf NCIT_C593 @default.