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- NCIT_C179647 IAO_0000115 "A T-cell engaging bispecific antibody directed against the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-PSMA/anti-CD3 T-cell engaging bispecific antibody TNB-585 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.
- NCIT_C179647 NCIT_A7 NCIT_C17796 @default.
- NCIT_C179647 NCIT_NHC0 "C179647" @default.
- NCIT_C179647 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179647 NCIT_P108 "Anti-PSMA/Anti-CD3 T-cell Engaging Bispecific Antibody TNB-585" @default.
- NCIT_C179647 NCIT_P208 "CL1662417" @default.
- NCIT_C179647 NCIT_P322 "GDC" @default.
- NCIT_C179647 NCIT_P399 "804939" @default.
- NCIT_C179647 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179647 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179647 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179647 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179647 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179647 normalizedInformationContent "100" @default.
- NCIT_C179647 referenceCount "1" @default.
- NCIT_C179647 hasExactSynonym "Anti-PSMA/Anti-CD3 T-cell Engaging Bispecific Antibody TNB-585" @default.
- NCIT_C179647 hasExactSynonym "PSMAxCD3 T-cell Engaging Bispecific Antibody TNB-585" @default.
- NCIT_C179647 hasExactSynonym "TNB 585" @default.
- NCIT_C179647 hasExactSynonym "TNB-585" @default.
- NCIT_C179647 hasExactSynonym "TNB585" @default.
- NCIT_C179647 inSubset NCIT_C128784 @default.
- NCIT_C179647 inSubset NCIT_C157711 @default.
- NCIT_C179647 inSubset NCIT_C157712 @default.
- NCIT_C179647 inSubset NCIT_C176424 @default.
- NCIT_C179647 type Class @default.
- NCIT_C179647 isDefinedBy ncit.owl @default.
- NCIT_C179647 label "Anti-PSMA/Anti-CD3 T-cell Engaging Bispecific Antibody TNB-585" @default.
- NCIT_C179647 subClassOf NCIT_C112883 @default.
- NCIT_C179647 subClassOf NCIT_C129821 @default.
- NCIT_C179647 subClassOf NCIT_C129822 @default.
- NCIT_C179647 subClassOf NCIT_C1454 @default.
- NCIT_C179647 subClassOf NCIT_C163758 @default.
- NCIT_C179647 subClassOf NCIT_C176017 @default.
- NCIT_C179647 subClassOf NCIT_C179647 @default.
- NCIT_C179647 subClassOf NCIT_C1908 @default.
- NCIT_C179647 subClassOf NCIT_C1909 @default.
- NCIT_C179647 subClassOf NCIT_C201282 @default.
- NCIT_C179647 subClassOf NCIT_C201543 @default.
- NCIT_C179647 subClassOf NCIT_C20401 @default.
- NCIT_C179647 subClassOf NCIT_C274 @default.
- NCIT_C179647 subClassOf NCIT_C28227 @default.
- NCIT_C179647 subClassOf NCIT_C307 @default.
- NCIT_C179647 subClassOf NCIT_C308 @default.