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- NCIT_C179655 IAO_0000115 "A fusion protein composed of fms-related tyrosine kinase 3 ligand (FLT3L) and agonist fused to an immunoglobulin (Ig) fragment crystallizable region (Fc region), with potential immunostimulating activity. Upon administration of the FLT3 agonist-Fc fusion protein GS-3583, the FLT3 agonist moiety specifically targets, binds to, and activates FLT3 and, synergistically with other growth factors, stimulates the proliferation and mobilization of bone marrow precursor cells, including CD34+ cells, and dendritic cells (DCs). FLT3 agonist-Fc fusion protein GS-3583 has a longer serum half-life compared with soluble FLT3L." @default.
- NCIT_C179655 NCIT_A7 NCIT_C26202 @default.
- NCIT_C179655 NCIT_NHC0 "C179655" @default.
- NCIT_C179655 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179655 NCIT_P107 "FLT3 Agonist-Fc Fusion Protein GS-3583" @default.
- NCIT_C179655 NCIT_P108 "FLT3 Agonist-Fc Fusion Protein GS-3583" @default.
- NCIT_C179655 NCIT_P208 "CL1662424" @default.
- NCIT_C179655 NCIT_P322 "CTRP" @default.
- NCIT_C179655 NCIT_P399 "804948" @default.
- NCIT_C179655 normalizedInformationContent "100" @default.
- NCIT_C179655 referenceCount "1" @default.
- NCIT_C179655 hasExactSynonym "FLT3 Agonist Fc Fusion Protein GS-3583" @default.
- NCIT_C179655 hasExactSynonym "FLT3 Agonist-Fc Fusion Protein GS-3583" @default.
- NCIT_C179655 hasExactSynonym "Flt3R Agonist GS-3583" @default.
- NCIT_C179655 hasExactSynonym "GS 3583" @default.
- NCIT_C179655 hasExactSynonym "GS-3583" @default.
- NCIT_C179655 hasExactSynonym "GS3583" @default.
- NCIT_C179655 inSubset NCIT_C116977 @default.
- NCIT_C179655 inSubset NCIT_C116978 @default.
- NCIT_C179655 inSubset NCIT_C176424 @default.
- NCIT_C179655 type Class @default.
- NCIT_C179655 isDefinedBy ncit.owl @default.
- NCIT_C179655 label "FLT3 Agonist-Fc Fusion Protein GS-3583" @default.
- NCIT_C179655 subClassOf NCIT_C179655 @default.
- NCIT_C179655 subClassOf NCIT_C1908 @default.
- NCIT_C179655 subClassOf NCIT_C1909 @default.
- NCIT_C179655 subClassOf NCIT_C308 @default.