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- NCIT_C179659 IAO_0000115 "A radioconjugate composed of FAPI-04, a quinoline-based fibroblast activation protein (FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi), conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-FAPI-04, the FAPI-04 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME)." @default.
- NCIT_C179659 NCIT_A7 NCIT_C17799 @default.
- NCIT_C179659 NCIT_NHC0 "C179659" @default.
- NCIT_C179659 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179659 NCIT_P108 "Gallium Ga 68-NOTA-FAPI-04" @default.
- NCIT_C179659 NCIT_P208 "CL1662407" @default.
- NCIT_C179659 NCIT_P399 "804951" @default.
- NCIT_C179659 normalizedInformationContent "100" @default.
- NCIT_C179659 referenceCount "1" @default.
- NCIT_C179659 hasExactSynonym "68Ga-NOTA-FAPI-04" @default.
- NCIT_C179659 hasExactSynonym "68Ga-NOTA-FAPI04" @default.
- NCIT_C179659 hasExactSynonym "Gallium Ga 68-NOTA-FAPI-04" @default.
- NCIT_C179659 hasExactSynonym "Gallium Ga 68-NOTA-FAPI04" @default.
- NCIT_C179659 inSubset NCIT_C176424 @default.
- NCIT_C179659 type Class @default.
- NCIT_C179659 isDefinedBy ncit.owl @default.
- NCIT_C179659 label "Gallium Ga 68-NOTA-FAPI-04" @default.
- NCIT_C179659 subClassOf NCIT_C1446 @default.
- NCIT_C179659 subClassOf NCIT_C179659 @default.
- NCIT_C179659 subClassOf NCIT_C1908 @default.
- NCIT_C179659 subClassOf NCIT_C1909 @default.
- NCIT_C179659 subClassOf NCIT_C2124 @default.