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- NCIT_C179662 IAO_0000115 "A bispecific antibody and T-cell engager directed against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/CD3 T-cell engager NVG-111 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and ROR1 found on ROR1-expressing tumor cells. This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival." @default.
- NCIT_C179662 NCIT_A7 NCIT_C29879 @default.
- NCIT_C179662 NCIT_NHC0 "C179662" @default.
- NCIT_C179662 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179662 NCIT_P108 "Anti-ROR1/CD3 T-cell Engager NVG-111" @default.
- NCIT_C179662 NCIT_P208 "CL1662404" @default.
- NCIT_C179662 NCIT_P322 "GDC" @default.
- NCIT_C179662 NCIT_P399 "804966" @default.
- NCIT_C179662 NCIT_R124 NCIT_C17710 @default.
- NCIT_C179662 NCIT_R124 NCIT_C17828 @default.
- NCIT_C179662 NCIT_R124 NCIT_C18219 @default.
- NCIT_C179662 NCIT_R124 NCIT_C19986 @default.
- NCIT_C179662 NCIT_R124 NCIT_C40474 @default.
- NCIT_C179662 normalizedInformationContent "100" @default.
- NCIT_C179662 referenceCount "1" @default.
- NCIT_C179662 hasExactSynonym "Anti-ROR1/CD3 Bispecific Antibody NVG-111" @default.
- NCIT_C179662 hasExactSynonym "Anti-ROR1/CD3 T-cell Engager NVG-111" @default.
- NCIT_C179662 hasExactSynonym "NVG 111" @default.
- NCIT_C179662 hasExactSynonym "NVG-111" @default.
- NCIT_C179662 hasExactSynonym "NVG111" @default.
- NCIT_C179662 inSubset NCIT_C128784 @default.
- NCIT_C179662 inSubset NCIT_C157711 @default.
- NCIT_C179662 inSubset NCIT_C157712 @default.
- NCIT_C179662 inSubset NCIT_C176424 @default.
- NCIT_C179662 type Class @default.
- NCIT_C179662 isDefinedBy ncit.owl @default.
- NCIT_C179662 label "Anti-ROR1/CD3 T-cell Engager NVG-111" @default.
- NCIT_C179662 subClassOf NCIT_C112883 @default.
- NCIT_C179662 subClassOf NCIT_C129821 @default.
- NCIT_C179662 subClassOf NCIT_C129822 @default.
- NCIT_C179662 subClassOf NCIT_C1454 @default.
- NCIT_C179662 subClassOf NCIT_C163758 @default.
- NCIT_C179662 subClassOf NCIT_C179662 @default.
- NCIT_C179662 subClassOf NCIT_C1908 @default.
- NCIT_C179662 subClassOf NCIT_C1909 @default.
- NCIT_C179662 subClassOf NCIT_C199675 @default.
- NCIT_C179662 subClassOf NCIT_C201282 @default.
- NCIT_C179662 subClassOf NCIT_C20401 @default.
- NCIT_C179662 subClassOf NCIT_C274 @default.
- NCIT_C179662 subClassOf NCIT_C28227 @default.
- NCIT_C179662 subClassOf NCIT_C307 @default.
- NCIT_C179662 subClassOf NCIT_C308 @default.