Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C179665> ?p ?o ?g. }
Showing items 1 to 34 of
34
with 100 items per page.
- NCIT_C179665 IAO_0000115 "A recombinant, humanized fusion protein composed of a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) fused to vascular endothelial growth factor receptor 1 (VEGFR-1/FLT-1), with potential anti-angiogenesis, immune checkpoint inhibitory and antineoplastic activities. Upon administration of sotiburafusp alfa, the anti-PD-L1 antibody moiety specifically targets and binds to PD-L1 expressing cells in the tumor microenvironment (TME). In turn, VEGFR-1 moiety binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to the endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis and metastasis, and ultimately tumor regression. PD-L1, a transmembrane protein, is expressed on the surface of antigen presenting cells (APCs) and on many cancer cell types. PD-L1 binding to PD-1, a negative regulator of the immune system on activated T-cells, limits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion." @default.
- NCIT_C179665 NCIT_A7 NCIT_C96024 @default.
- NCIT_C179665 NCIT_NHC0 "C179665" @default.
- NCIT_C179665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179665 NCIT_P108 "Sotiburafusp Alfa" @default.
- NCIT_C179665 NCIT_P208 "CL1662405" @default.
- NCIT_C179665 NCIT_P210 "2637466-37-4" @default.
- NCIT_C179665 NCIT_P319 "34DTV38QW5" @default.
- NCIT_C179665 NCIT_P322 "FDA" @default.
- NCIT_C179665 NCIT_P322 "GDC" @default.
- NCIT_C179665 NCIT_P399 "804808" @default.
- NCIT_C179665 normalizedInformationContent "100" @default.
- NCIT_C179665 referenceCount "1" @default.
- NCIT_C179665 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody/VEGFR1 Fusion Protein HB0025" @default.
- NCIT_C179665 hasExactSynonym "Anti-PD-L1/VEGFR-1 Fusion Protein HB0025" @default.
- NCIT_C179665 hasExactSynonym "HB 0025" @default.
- NCIT_C179665 hasExactSynonym "HB-0025" @default.
- NCIT_C179665 hasExactSynonym "HB0025" @default.
- NCIT_C179665 hasExactSynonym "SOTIBURAFUSP ALFA" @default.
- NCIT_C179665 hasExactSynonym "Sotiburafusp Alfa" @default.
- NCIT_C179665 inSubset NCIT_C128784 @default.
- NCIT_C179665 inSubset NCIT_C157711 @default.
- NCIT_C179665 inSubset NCIT_C157712 @default.
- NCIT_C179665 inSubset NCIT_C176424 @default.
- NCIT_C179665 inSubset NCIT_C63923 @default.
- NCIT_C179665 type Class @default.
- NCIT_C179665 isDefinedBy ncit.owl @default.
- NCIT_C179665 label "Sotiburafusp Alfa" @default.
- NCIT_C179665 subClassOf NCIT_C129820 @default.
- NCIT_C179665 subClassOf NCIT_C179665 @default.
- NCIT_C179665 subClassOf NCIT_C1908 @default.
- NCIT_C179665 subClassOf NCIT_C1909 @default.
- NCIT_C179665 subClassOf NCIT_C274 @default.
- NCIT_C179665 subClassOf NCIT_C308 @default.