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- NCIT_C179670 IAO_0000115 "A cancer cell vaccine consisting of autologous monocytes loaded with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion protein with the lysosome-associated membrane protein (LAMP), with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous CMV-pp65-LAMP mRNA loaded monocyte vaccine MT-201-GBM exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of LAMP may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types." @default.
- NCIT_C179670 NCIT_A7 NCIT_C141213 @default.
- NCIT_C179670 NCIT_NHC0 "C179670" @default.
- NCIT_C179670 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179670 NCIT_P108 "Autologous CMV-pp65-LAMP mRNA Loaded Monocyte Vaccine MT-201-GBM" @default.
- NCIT_C179670 NCIT_P208 "CL1662412" @default.
- NCIT_C179670 NCIT_P322 "GDC" @default.
- NCIT_C179670 NCIT_P399 "804940" @default.
- NCIT_C179670 normalizedInformationContent "100" @default.
- NCIT_C179670 referenceCount "1" @default.
- NCIT_C179670 hasExactSynonym "Autologous CMV-pp65-LAMP mRNA Loaded Monocyte Vaccine MT-201-GBM" @default.
- NCIT_C179670 hasExactSynonym "MT 201-GBM" @default.
- NCIT_C179670 hasExactSynonym "MT-201-GBM" @default.
- NCIT_C179670 hasExactSynonym "MT201-GBM" @default.
- NCIT_C179670 hasExactSynonym "Monocyte Antigen Carrier Cells MT-201-GBM" @default.
- NCIT_C179670 inSubset NCIT_C128784 @default.
- NCIT_C179670 inSubset NCIT_C157711 @default.
- NCIT_C179670 inSubset NCIT_C157712 @default.
- NCIT_C179670 inSubset NCIT_C176424 @default.
- NCIT_C179670 type Class @default.
- NCIT_C179670 isDefinedBy ncit.owl @default.
- NCIT_C179670 label "Autologous CMV-pp65-LAMP mRNA Loaded Monocyte Vaccine MT-201-GBM" @default.
- NCIT_C179670 subClassOf NCIT_C129820 @default.
- NCIT_C179670 subClassOf NCIT_C1663 @default.
- NCIT_C179670 subClassOf NCIT_C172787 @default.
- NCIT_C179670 subClassOf NCIT_C179670 @default.
- NCIT_C179670 subClassOf NCIT_C181141 @default.
- NCIT_C179670 subClassOf NCIT_C1908 @default.
- NCIT_C179670 subClassOf NCIT_C1909 @default.
- NCIT_C179670 subClassOf NCIT_C274 @default.
- NCIT_C179670 subClassOf NCIT_C28308 @default.
- NCIT_C179670 subClassOf NCIT_C307 @default.
- NCIT_C179670 subClassOf NCIT_C308 @default.
- NCIT_C179670 subClassOf NCIT_C923 @default.