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- NCIT_C179672 IAO_0000115 "A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the Evans blue (EB) moiety and linked via the macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 EB-PSMA-617, EB-PSMA-617 targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. EB-PSMA-617 also binds to serum albumin, which extends its circulation half-life. This may improve tumor uptake and efficacy of the agent." @default.
- NCIT_C179672 NCIT_A7 NCIT_C17796 @default.
- NCIT_C179672 NCIT_NHC0 "C179672" @default.
- NCIT_C179672 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179672 NCIT_P108 "Lutetium Lu 177 EB-PSMA-617" @default.
- NCIT_C179672 NCIT_P208 "CL1662413" @default.
- NCIT_C179672 NCIT_P322 "GDC" @default.
- NCIT_C179672 NCIT_P399 "804999" @default.
- NCIT_C179672 normalizedInformationContent "100" @default.
- NCIT_C179672 referenceCount "1" @default.
- NCIT_C179672 hasExactSynonym "177 Lu-EB-PSMA-617" @default.
- NCIT_C179672 hasExactSynonym "177Lu-EB-PSMA-617" @default.
- NCIT_C179672 hasExactSynonym "177Lu-Evans Blue-modified PSMA-617" @default.
- NCIT_C179672 hasExactSynonym "Lutetium Lu 177 EB-PSMA-617" @default.
- NCIT_C179672 hasExactSynonym "Lutetium Lu 177-DOTA-EB-PSMA-617" @default.
- NCIT_C179672 hasExactSynonym "Lutetium Lu 177-EB-PSMA-617" @default.
- NCIT_C179672 inSubset NCIT_C128784 @default.
- NCIT_C179672 inSubset NCIT_C157711 @default.
- NCIT_C179672 inSubset NCIT_C157712 @default.
- NCIT_C179672 inSubset NCIT_C176424 @default.
- NCIT_C179672 type Class @default.
- NCIT_C179672 isDefinedBy ncit.owl @default.
- NCIT_C179672 label "Lutetium Lu 177 EB-PSMA-617" @default.
- NCIT_C179672 subClassOf NCIT_C129819 @default.
- NCIT_C179672 subClassOf NCIT_C1446 @default.
- NCIT_C179672 subClassOf NCIT_C179672 @default.
- NCIT_C179672 subClassOf NCIT_C1908 @default.
- NCIT_C179672 subClassOf NCIT_C1909 @default.
- NCIT_C179672 subClassOf NCIT_C2124 @default.
- NCIT_C179672 subClassOf NCIT_C274 @default.