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- NCIT_C179714 IAO_0000115 "The trifluoroacetate (TFA) salt form of teverelix, a synthetic decapeptide and antagonist of the naturally occurring gonadotropin-releasing hormone (GnRH), with potential hormone production inhibitory and antineoplastic activities. Upon administration, teverelix directly competes with GnRH for receptor binding in the anterior pituitary gland, thereby inhibiting GnRH receptor signaling. This inhibits the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. In females, this prevents the production of estrogen by the ovaries and may relieve symptoms from sex-hormone dependent diseases." @default.
- NCIT_C179714 NCIT_A7 NCIT_C38910 @default.
- NCIT_C179714 NCIT_NHC0 "C179714" @default.
- NCIT_C179714 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179714 NCIT_P108 "Teverelix Trifluoroacetate" @default.
- NCIT_C179714 NCIT_P208 "CL1662475" @default.
- NCIT_C179714 NCIT_P210 "244792-29-8" @default.
- NCIT_C179714 NCIT_P319 "J5OUL9SHW5" @default.
- NCIT_C179714 NCIT_P322 "FDA" @default.
- NCIT_C179714 NCIT_P399 "804852" @default.
- NCIT_C179714 normalizedInformationContent "100" @default.
- NCIT_C179714 referenceCount "1" @default.
- NCIT_C179714 hasExactSynonym "TEVERELIX TRIFLUOROACETATE" @default.
- NCIT_C179714 hasExactSynonym "Teverelix TFA" @default.
- NCIT_C179714 hasExactSynonym "Teverelix Trifluoroacetate" @default.
- NCIT_C179714 hasExactSynonym "d-Alaninamide, N-acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-N6-(aminocarbonyl)-d-lysyl-l-leucyl-n6-(1-methylethyl)-l-lysyl-l-prolyl-, Bis(trifluoroacetate) (Salt)" @default.
- NCIT_C179714 inSubset NCIT_C128784 @default.
- NCIT_C179714 inSubset NCIT_C176424 @default.
- NCIT_C179714 inSubset NCIT_C63923 @default.
- NCIT_C179714 type Class @default.
- NCIT_C179714 isDefinedBy ncit.owl @default.
- NCIT_C179714 label "Teverelix Trifluoroacetate" @default.
- NCIT_C179714 subClassOf NCIT_C147908 @default.
- NCIT_C179714 subClassOf NCIT_C179714 @default.
- NCIT_C179714 subClassOf NCIT_C1908 @default.
- NCIT_C179714 subClassOf NCIT_C1909 @default.
- NCIT_C179714 subClassOf NCIT_C2092 @default.
- NCIT_C179714 subClassOf NCIT_C547 @default.