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- NCIT_C179722 IAO_0000115 "A sustained-release (SR) injectable microsphere formulation composed of the acetate salt of leuprolide, a synthetic, long-acting nonapeptide analog of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In females, prolonged administration results in a decrease in estradiol production and suppression of ovarian function. Leuprolide also reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.
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- NCIT_C179722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179722 NCIT_P108 "Leuprolide Acetate Sustained-release Microspheres PT105" @default.
- NCIT_C179722 NCIT_P208 "CL1662461" @default.
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- NCIT_C179722 normalizedInformationContent "100" @default.
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- NCIT_C179722 hasExactSynonym "Leuprolide Acetate Sustained-release Microspheres PT105" @default.
- NCIT_C179722 hasExactSynonym "Leuprorelin Acetate Sustained-release Microspheres PT105" @default.
- NCIT_C179722 hasExactSynonym "PT 105" @default.
- NCIT_C179722 hasExactSynonym "PT-105" @default.
- NCIT_C179722 hasExactSynonym "PT105" @default.
- NCIT_C179722 hasExactSynonym "SR PT105" @default.
- NCIT_C179722 inSubset NCIT_C128784 @default.
- NCIT_C179722 inSubset NCIT_C157711 @default.
- NCIT_C179722 inSubset NCIT_C157712 @default.
- NCIT_C179722 inSubset NCIT_C176424 @default.
- NCIT_C179722 type Class @default.
- NCIT_C179722 isDefinedBy ncit.owl @default.
- NCIT_C179722 label "Leuprolide Acetate Sustained-release Microspheres PT105" @default.
- NCIT_C179722 subClassOf B1dc16c2db19035040e9401beb651538e @default.
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- NCIT_C179722 subClassOf NCIT_C548 @default.