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- NCIT_C179831 IAO_0000115 "A human bispecific immunoglobulin G1 (IgG1) antibody targeting the tumor-associated antigens (TAAs) epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met bispecific antibody MCLA-129 simultaneously targets and binds to the extracellular domains of both EGFR and c-Met expressed on cancer cells. This prevents the activation of both EGFR- and c-Met-mediated signaling pathways. The binding results in antibody-dependent cellular cytotoxicity (ADCC), thereby inhibiting tumor cell proliferation and survival. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation." @default.
- NCIT_C179831 NCIT_A7 NCIT_C17068 @default.
- NCIT_C179831 NCIT_A7 NCIT_C18186 @default.
- NCIT_C179831 NCIT_NHC0 "C179831" @default.
- NCIT_C179831 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C179831 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C179831 NCIT_P107 "Anti-EGFR/c-Met Bispecific Antibody MCLA-129" @default.
- NCIT_C179831 NCIT_P108 "Anti-EGFR/c-Met Bispecific Antibody MCLA-129" @default.
- NCIT_C179831 NCIT_P208 "CL1662318" @default.
- NCIT_C179831 NCIT_P322 "CTRP" @default.
- NCIT_C179831 NCIT_P322 "GDC" @default.
- NCIT_C179831 NCIT_P399 "805718" @default.
- NCIT_C179831 normalizedInformationContent "100" @default.
- NCIT_C179831 referenceCount "1" @default.
- NCIT_C179831 hasExactSynonym "Anti-EGFR/c-Met Bispecific Antibody MCLA-129" @default.
- NCIT_C179831 hasExactSynonym "Bispecific EGFR-c-Met Antibody MCLA-129" @default.
- NCIT_C179831 hasExactSynonym "MCLA 129" @default.
- NCIT_C179831 hasExactSynonym "MCLA-129" @default.
- NCIT_C179831 hasExactSynonym "MCLA129" @default.
- NCIT_C179831 inSubset NCIT_C116977 @default.
- NCIT_C179831 inSubset NCIT_C116978 @default.
- NCIT_C179831 inSubset NCIT_C128784 @default.
- NCIT_C179831 inSubset NCIT_C157711 @default.
- NCIT_C179831 inSubset NCIT_C157712 @default.
- NCIT_C179831 inSubset NCIT_C176424 @default.
- NCIT_C179831 type Class @default.
- NCIT_C179831 isDefinedBy ncit.owl @default.
- NCIT_C179831 label "Anti-EGFR/c-Met Bispecific Antibody MCLA-129" @default.
- NCIT_C179831 subClassOf NCIT_C1454 @default.
- NCIT_C179831 subClassOf NCIT_C179831 @default.
- NCIT_C179831 subClassOf NCIT_C1908 @default.
- NCIT_C179831 subClassOf NCIT_C1909 @default.
- NCIT_C179831 subClassOf NCIT_C307 @default.
- NCIT_C179831 subClassOf NCIT_C308 @default.