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- NCIT_C180326 IAO_0000115 "An orally bioavailable ATP-competitive inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, lartesertib targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, by preventing DNA damage repair, M4076 sensitizes tumor cells to chemo- and radiotherapy and increases their anti-tumor activity. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair." @default.
- NCIT_C180326 NCIT_A7 NCIT_C17924 @default.
- NCIT_C180326 NCIT_NHC0 "C180326" @default.
- NCIT_C180326 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180326 NCIT_P107 "Lartesertib" @default.
- NCIT_C180326 NCIT_P108 "Lartesertib" @default.
- NCIT_C180326 NCIT_P208 "CL1662749" @default.
- NCIT_C180326 NCIT_P210 "2020089-41-0" @default.
- NCIT_C180326 NCIT_P319 "KL7B6D38VC" @default.
- NCIT_C180326 NCIT_P322 "CTRP" @default.
- NCIT_C180326 NCIT_P322 "FDA" @default.
- NCIT_C180326 NCIT_P322 "GDC" @default.
- NCIT_C180326 NCIT_P399 "805576" @default.
- NCIT_C180326 normalizedInformationContent "100" @default.
- NCIT_C180326 referenceCount "1" @default.
- NCIT_C180326 hasExactSynonym "ATM Kinase Inhibitor M4076" @default.
- NCIT_C180326 hasExactSynonym "Ataxia Telangiectasia Mutated Kinase Inhibitor M4076" @default.
- NCIT_C180326 hasExactSynonym "LARTESERTIB" @default.
- NCIT_C180326 hasExactSynonym "Lartesertib" @default.
- NCIT_C180326 hasExactSynonym "M 4076" @default.
- NCIT_C180326 hasExactSynonym "M-4076" @default.
- NCIT_C180326 hasExactSynonym "M4076" @default.
- NCIT_C180326 inSubset NCIT_C116977 @default.
- NCIT_C180326 inSubset NCIT_C116978 @default.
- NCIT_C180326 inSubset NCIT_C128784 @default.
- NCIT_C180326 inSubset NCIT_C157711 @default.
- NCIT_C180326 inSubset NCIT_C157712 @default.
- NCIT_C180326 inSubset NCIT_C176424 @default.
- NCIT_C180326 inSubset NCIT_C63923 @default.
- NCIT_C180326 type Class @default.
- NCIT_C180326 isDefinedBy ncit.owl @default.
- NCIT_C180326 label "Lartesertib" @default.
- NCIT_C180326 subClassOf NCIT_C129824 @default.
- NCIT_C180326 subClassOf NCIT_C129825 @default.
- NCIT_C180326 subClassOf NCIT_C1404 @default.
- NCIT_C180326 subClassOf NCIT_C180326 @default.
- NCIT_C180326 subClassOf NCIT_C1908 @default.
- NCIT_C180326 subClassOf NCIT_C1909 @default.
- NCIT_C180326 subClassOf NCIT_C2189 @default.
- NCIT_C180326 subClassOf NCIT_C274 @default.
- NCIT_C180326 subClassOf NCIT_C471 @default.
- NCIT_C180326 subClassOf NCIT_C61074 @default.