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- NCIT_C180409 IAO_0000115 "A sub-micron spray containing a nanoparticle water soluble equimolar solution composed of delta-9-tetrahydrocannabinol (delta-9-THC; d9-THC), an analogue of tetrahydrocannabinol (THC) and the primary form of THC found in the Cannabis sativa L. plant, and cannabidiol (CBD), a phytocannabinoid derived from Cannabis species, with potential analgesic activity. Upon administration to the oro-buccal membrane, d9-THC/CBD combination agent binds to and activates the cannabinoid G-protein coupled receptor (CBR) located in the central nervous system (CNS). This activates the inwardly rectifying potassium channels, which decrease presynaptic neuron firing, and inhibits voltage-sensitive calcium channels that decrease neurotransmitter release. This inhibits excitatory postsynaptic neuronal transmission, and inhibits the release of pro-inflammatory mediators. This provides an analgesic effect." @default.
- NCIT_C180409 NCIT_NHC0 "C180409" @default.
- NCIT_C180409 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180409 NCIT_P108 "delta9-Tetrahydrocannabinol/Cannabidiol Combination Agent" @default.
- NCIT_C180409 NCIT_P208 "CL1662766" @default.
- NCIT_C180409 NCIT_P399 "805126" @default.
- NCIT_C180409 normalizedInformationContent "100" @default.
- NCIT_C180409 referenceCount "1" @default.
- NCIT_C180409 hasExactSynonym "MDCNB-01" @default.
- NCIT_C180409 hasExactSynonym "NanaBis" @default.
- NCIT_C180409 hasExactSynonym "d9-THC/CBD Nanoparticle-based Combination Agent" @default.
- NCIT_C180409 hasExactSynonym "delta9-Tetrahydrocannabinol/Cannabidiol Combination Agent" @default.
- NCIT_C180409 inSubset NCIT_C176424 @default.
- NCIT_C180409 type Class @default.
- NCIT_C180409 isDefinedBy ncit.owl @default.
- NCIT_C180409 label "delta9-Tetrahydrocannabinol/Cannabidiol Combination Agent" @default.
- NCIT_C180409 subClassOf NCIT_C180409 @default.
- NCIT_C180409 subClassOf NCIT_C1908 @default.
- NCIT_C180409 subClassOf NCIT_C1909 @default.
- NCIT_C180409 subClassOf NCIT_C2198 @default.
- NCIT_C180409 subClassOf NCIT_C241 @default.
- NCIT_C180409 subClassOf NCIT_C267 @default.
- NCIT_C180409 subClassOf NCIT_C78272 @default.