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- NCIT_C180410 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the immune inhibitory receptor leukocyte immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, autologous anti-ILT3 CAR-T cells target and bind to ILT3-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against ILT3-expressing tumor cells. ILT3, a tumor associated antigen (TAA) and an immune inhibitory receptor expressed on immune suppressive myeloid cells, is highly expressed on certain hematologic cancer cells, such as monocytic acute myeloid leukemia (AML) cells. It functions as an immune checkpoint that negatively regulates T-cell activation as its extracellular domain inhibits T-cell activity. It plays an important role in tumor infiltration, T-cell suppression and immune tolerance." @default.
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- NCIT_C180410 NCIT_P108 "Autologous Anti-ILT3 CAR-T Cells" @default.
- NCIT_C180410 NCIT_P208 "CL1662769" @default.
- NCIT_C180410 NCIT_P399 "805127" @default.
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- NCIT_C180410 normalizedInformationContent "100" @default.
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- NCIT_C180410 hasExactSynonym "Autologous Anti-ILT3 CAR-T Cells" @default.
- NCIT_C180410 hasExactSynonym "Autologous Anti-LILRB4 CAR-T Cells" @default.
- NCIT_C180410 hasExactSynonym "Autologous ILT3-targeted CAR-T Cells" @default.
- NCIT_C180410 hasExactSynonym "Autologous LILRB4-targeted CAR-T Cells" @default.
- NCIT_C180410 inSubset NCIT_C128784 @default.
- NCIT_C180410 inSubset NCIT_C176424 @default.
- NCIT_C180410 type Class @default.
- NCIT_C180410 isDefinedBy ncit.owl @default.
- NCIT_C180410 label "Autologous Anti-ILT3 CAR-T Cells" @default.
- NCIT_C180410 subClassOf NCIT_C129820 @default.
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