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- NCIT_C180412 IAO_0000115 "An orally bioavailable and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon oral administration, BTK inhibitor ABBV-992 targets, binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies. It plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C180412 NCIT_NHC0 "C180412" @default.
- NCIT_C180412 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180412 NCIT_P108 "BTK Inhibitor ABBV-992" @default.
- NCIT_C180412 NCIT_P208 "CL1663034" @default.
- NCIT_C180412 NCIT_P322 "GDC" @default.
- NCIT_C180412 NCIT_P399 "805130" @default.
- NCIT_C180412 normalizedInformationContent "100" @default.
- NCIT_C180412 referenceCount "1" @default.
- NCIT_C180412 hasExactSynonym "ABBV 992" @default.
- NCIT_C180412 hasExactSynonym "ABBV-992" @default.
- NCIT_C180412 hasExactSynonym "ABBV992" @default.
- NCIT_C180412 hasExactSynonym "BTK Inhibitor ABBV-992" @default.
- NCIT_C180412 inSubset NCIT_C128784 @default.
- NCIT_C180412 inSubset NCIT_C157711 @default.
- NCIT_C180412 inSubset NCIT_C157712 @default.
- NCIT_C180412 inSubset NCIT_C176424 @default.
- NCIT_C180412 type Class @default.
- NCIT_C180412 isDefinedBy ncit.owl @default.
- NCIT_C180412 label "BTK Inhibitor ABBV-992" @default.
- NCIT_C180412 subClassOf NCIT_C124801 @default.
- NCIT_C180412 subClassOf NCIT_C129824 @default.
- NCIT_C180412 subClassOf NCIT_C129825 @default.
- NCIT_C180412 subClassOf NCIT_C1404 @default.
- NCIT_C180412 subClassOf NCIT_C163758 @default.
- NCIT_C180412 subClassOf NCIT_C163774 @default.
- NCIT_C180412 subClassOf NCIT_C180412 @default.
- NCIT_C180412 subClassOf NCIT_C1908 @default.
- NCIT_C180412 subClassOf NCIT_C1909 @default.
- NCIT_C180412 subClassOf NCIT_C1967 @default.
- NCIT_C180412 subClassOf NCIT_C2189 @default.
- NCIT_C180412 subClassOf NCIT_C274 @default.
- NCIT_C180412 subClassOf NCIT_C471 @default.