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- NCIT_C180413 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) conjugated via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, anti-CLDN18.2 ADC CMG901 specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C180413 NCIT_A7 NCIT_C150412 @default.
- NCIT_C180413 NCIT_NHC0 "C180413" @default.
- NCIT_C180413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180413 NCIT_P108 "Anti-Claudin18.2 ADC CMG901" @default.
- NCIT_C180413 NCIT_P208 "CL1663033" @default.
- NCIT_C180413 NCIT_P322 "GDC" @default.
- NCIT_C180413 NCIT_P399 "805131" @default.
- NCIT_C180413 normalizedInformationContent "100" @default.
- NCIT_C180413 referenceCount "1" @default.
- NCIT_C180413 hasExactSynonym "Anti-CLDN18.2 ADC CMG901" @default.
- NCIT_C180413 hasExactSynonym "Anti-Claudin18.2 ADC CMG901" @default.
- NCIT_C180413 hasExactSynonym "CM G901" @default.
- NCIT_C180413 hasExactSynonym "CM-G901" @default.
- NCIT_C180413 hasExactSynonym "CMG901" @default.
- NCIT_C180413 inSubset NCIT_C128784 @default.
- NCIT_C180413 inSubset NCIT_C157711 @default.
- NCIT_C180413 inSubset NCIT_C157712 @default.
- NCIT_C180413 inSubset NCIT_C176424 @default.
- NCIT_C180413 type Class @default.
- NCIT_C180413 isDefinedBy ncit.owl @default.
- NCIT_C180413 label "Anti-Claudin18.2 ADC CMG901" @default.
- NCIT_C180413 subClassOf NCIT_C129821 @default.
- NCIT_C180413 subClassOf NCIT_C129823 @default.
- NCIT_C180413 subClassOf NCIT_C1512 @default.
- NCIT_C180413 subClassOf NCIT_C163758 @default.
- NCIT_C180413 subClassOf NCIT_C180413 @default.
- NCIT_C180413 subClassOf NCIT_C1908 @default.
- NCIT_C180413 subClassOf NCIT_C1909 @default.
- NCIT_C180413 subClassOf NCIT_C200250 @default.
- NCIT_C180413 subClassOf NCIT_C200251 @default.
- NCIT_C180413 subClassOf NCIT_C274 @default.
- NCIT_C180413 subClassOf NCIT_C307 @default.
- NCIT_C180413 subClassOf NCIT_C308 @default.