Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C180420> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- NCIT_C180420 IAO_0000115 "An orally available, compact macrocyclic structure-based inhibitor of the receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, zotizalkib binds within the ATP binding boundary and inhibits ALK wild-type tyrosine kinase, ALK fusion proteins and numerous ALK point mutations, including acquired resistance mutations, such as the solvent front mutation (SFM) G1202R and compound mutations L1196M/G1202R, L1198F/G1202R, L1196M/L1198F, and C1156Y/G1202R. Inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types. Compared to other ALK inhibitors, zotizalkib is able to inhibit ALK resistance mutations associated with acquired resistance to other ALK inhibitors." @default.
- NCIT_C180420 NCIT_A7 NCIT_C27032 @default.
- NCIT_C180420 NCIT_NHC0 "C180420" @default.
- NCIT_C180420 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180420 NCIT_P107 "Zotizalkib" @default.
- NCIT_C180420 NCIT_P108 "Zotizalkib" @default.
- NCIT_C180420 NCIT_P208 "CL1663039" @default.
- NCIT_C180420 NCIT_P210 "2648641-36-3" @default.
- NCIT_C180420 NCIT_P319 "5BKJ4Z6RBU" @default.
- NCIT_C180420 NCIT_P322 "CTRP" @default.
- NCIT_C180420 NCIT_P322 "FDA" @default.
- NCIT_C180420 NCIT_P322 "GDC" @default.
- NCIT_C180420 NCIT_P399 "805534" @default.
- NCIT_C180420 normalizedInformationContent "100" @default.
- NCIT_C180420 referenceCount "1" @default.
- NCIT_C180420 hasExactSynonym "ALK Inhibitor TPX-0131" @default.
- NCIT_C180420 hasExactSynonym "TPX 0131" @default.
- NCIT_C180420 hasExactSynonym "TPX-0131" @default.
- NCIT_C180420 hasExactSynonym "TPX0131" @default.
- NCIT_C180420 hasExactSynonym "Zotizalkib" @default.
- NCIT_C180420 inSubset NCIT_C116977 @default.
- NCIT_C180420 inSubset NCIT_C116978 @default.
- NCIT_C180420 inSubset NCIT_C128784 @default.
- NCIT_C180420 inSubset NCIT_C157711 @default.
- NCIT_C180420 inSubset NCIT_C157712 @default.
- NCIT_C180420 inSubset NCIT_C176424 @default.
- NCIT_C180420 inSubset NCIT_C63923 @default.
- NCIT_C180420 type Class @default.
- NCIT_C180420 isDefinedBy ncit.owl @default.
- NCIT_C180420 label "Zotizalkib" @default.
- NCIT_C180420 subClassOf NCIT_C129824 @default.
- NCIT_C180420 subClassOf NCIT_C129825 @default.
- NCIT_C180420 subClassOf NCIT_C1404 @default.
- NCIT_C180420 subClassOf NCIT_C141136 @default.
- NCIT_C180420 subClassOf NCIT_C163758 @default.
- NCIT_C180420 subClassOf NCIT_C180420 @default.
- NCIT_C180420 subClassOf NCIT_C1908 @default.
- NCIT_C180420 subClassOf NCIT_C1909 @default.
- NCIT_C180420 subClassOf NCIT_C1967 @default.
- NCIT_C180420 subClassOf NCIT_C2189 @default.
- NCIT_C180420 subClassOf NCIT_C274 @default.
- NCIT_C180420 subClassOf NCIT_C471 @default.