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- NCIT_C180425 IAO_0000115 "An orally bioavailable inhibitor of mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2; IDH-2) R140Q mutant, with potential antineoplastic activity. Upon oral administration, IDH2 mutant inhibitor SH1573 specifically inhibits mutant IDH2 (mIDH2) R140Q protein, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing mIDH2 R140Q. IDH2 is mutated in a variety of cancers, and mutated IDH2 initiates and drives cancer growth by catalyzing the formation of 2HG and blocking cell differentiation." @default.
- NCIT_C180425 NCIT_NHC0 "C180425" @default.
- NCIT_C180425 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180425 NCIT_P108 "IDH2 Mutant Inhibitor SH1573" @default.
- NCIT_C180425 NCIT_P208 "CL1663036" @default.
- NCIT_C180425 NCIT_P322 "GDC" @default.
- NCIT_C180425 NCIT_P399 "805133" @default.
- NCIT_C180425 normalizedInformationContent "100" @default.
- NCIT_C180425 referenceCount "1" @default.
- NCIT_C180425 hasExactSynonym "IDH2 Mutant Inhibitor SH1573" @default.
- NCIT_C180425 hasExactSynonym "IDH2 R140Q Mutant Inhibitor SH1573" @default.
- NCIT_C180425 hasExactSynonym "SH 1573" @default.
- NCIT_C180425 hasExactSynonym "SH-1573" @default.
- NCIT_C180425 hasExactSynonym "SH1573" @default.
- NCIT_C180425 hasExactSynonym "mIDH2 Inhibitor SH1573" @default.
- NCIT_C180425 inSubset NCIT_C128784 @default.
- NCIT_C180425 inSubset NCIT_C157711 @default.
- NCIT_C180425 inSubset NCIT_C157712 @default.
- NCIT_C180425 inSubset NCIT_C176424 @default.
- NCIT_C180425 type Class @default.
- NCIT_C180425 isDefinedBy ncit.owl @default.
- NCIT_C180425 label "IDH2 Mutant Inhibitor SH1573" @default.
- NCIT_C180425 subClassOf NCIT_C129824 @default.
- NCIT_C180425 subClassOf NCIT_C129825 @default.
- NCIT_C180425 subClassOf NCIT_C137826 @default.
- NCIT_C180425 subClassOf NCIT_C163758 @default.
- NCIT_C180425 subClassOf NCIT_C168619 @default.
- NCIT_C180425 subClassOf NCIT_C180425 @default.
- NCIT_C180425 subClassOf NCIT_C1908 @default.
- NCIT_C180425 subClassOf NCIT_C1909 @default.
- NCIT_C180425 subClassOf NCIT_C2189 @default.
- NCIT_C180425 subClassOf NCIT_C274 @default.
- NCIT_C180425 subClassOf NCIT_C471 @default.