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- NCIT_C180506 IAO_0000115 "A transforming growth factor (TGF)-beta2 specific antisense oligodeoxynucleotide (ASO), with potential antineoplastic activity. Upon administration, TGF-beta2 ASO TASO-001 binds to TGF-beta2 mRNA causing inhibition of protein translation. This decreases TGF-beta2 levels, which may result in the inhibition of tumor cell growth and migration, and tumor angiogenesis. TGF-beta2, a cytokine overexpressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells." @default.
- NCIT_C180506 NCIT_A7 NCIT_C20458 @default.
- NCIT_C180506 NCIT_NHC0 "C180506" @default.
- NCIT_C180506 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180506 NCIT_P108 "TGF-beta2 Antisense Oligonucleotide TASO-001" @default.
- NCIT_C180506 NCIT_P208 "CL1663083" @default.
- NCIT_C180506 NCIT_P322 "GDC" @default.
- NCIT_C180506 NCIT_P399 "805135" @default.
- NCIT_C180506 normalizedInformationContent "100" @default.
- NCIT_C180506 referenceCount "1" @default.
- NCIT_C180506 hasExactSynonym "TASO 001" @default.
- NCIT_C180506 hasExactSynonym "TASO-001" @default.
- NCIT_C180506 hasExactSynonym "TASO001" @default.
- NCIT_C180506 hasExactSynonym "TGF-beta2 ASO TASO-001" @default.
- NCIT_C180506 hasExactSynonym "TGF-beta2 Antisense Oligonucleotide TASO-001" @default.
- NCIT_C180506 hasExactSynonym "TGF-beta2-targeting Antisense Oligonucleotide TASO-001" @default.
- NCIT_C180506 inSubset NCIT_C128784 @default.
- NCIT_C180506 inSubset NCIT_C157711 @default.
- NCIT_C180506 inSubset NCIT_C157712 @default.
- NCIT_C180506 inSubset NCIT_C176424 @default.
- NCIT_C180506 type Class @default.
- NCIT_C180506 isDefinedBy ncit.owl @default.
- NCIT_C180506 label "TGF-beta2 Antisense Oligonucleotide TASO-001" @default.
- NCIT_C180506 subClassOf NCIT_C1291 @default.
- NCIT_C180506 subClassOf NCIT_C180506 @default.
- NCIT_C180506 subClassOf NCIT_C1908 @default.
- NCIT_C180506 subClassOf NCIT_C1909 @default.
- NCIT_C180506 subClassOf NCIT_C1962 @default.
- NCIT_C180506 subClassOf NCIT_C307 @default.